PELI2 and TIMM9

		PELI2	TIMM9
Description		pellino E3 ubiquitin protein ligase family member 2	translocase of inner mitochondrial membrane 9
Image
GO Annotations	Cellular Component	Cytosol	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Intermembrane Space Chaperone Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex
	Molecular Function	Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Membrane Insertase Activity Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding Protein Transporter Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade	Protein Targeting To Mitochondrion Sensory Perception Of Sound Protein Transport Protein Insertion Into Mitochondrial Inner Membrane
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Mitochondrial protein import Mitochondrial protein import Mitochondrial protein degradation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		44 interacting genes: BCL10 CEP170B CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 IRS1 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MPDZ MYD88 MYO10 NEK9 NUP62 OR7D2 PCGF2 PICALM PRR36 RABEP1 RBBP8 REL RMDN3 RNF220 SEPTIN3 SP4 SRPK1 TGM2 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4 YTHDF2
Entrez ID		57161	26520
HPRD ID		17835	09574
Ensembl ID		ENSG00000139946	ENSG00000100575
Uniprot IDs		Q9H716 Q9HAT8	A0A1W2PQS5 A0A1W2PRH9 G3V502 Q9Y5J7
PDB IDs		3EGA 3EGB	2BSK 7CGP
Enriched GO Terms of Interacting Partners?		Toll Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response-activating Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Activation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Adaptor Activity Anatomical Structure Morphogenesis Regulation Of Apoptotic Signaling Pathway Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Defense Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Response To Stress Regulation Of Cell Communication Cellular Developmental Process Regulation Of Signaling Regulation Of Gene Expression Positive Regulation Of DNA-binding Transcription Factor Activity	Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Regulation Of Toll Signaling Pathway Protein N-linked Glycosylation Via Asparagine Viral Protein Processing Oligosaccharide Biosynthetic Process Ubiquitin-ubiquitin Ligase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?