IRAK4 and IRAK1

Number of citations of the paper that reports this interaction (PubMedID 11960013)
27

Data Source:
HPRD (in vitro, in vivo)

		IRAK4	IRAK1
Description		interleukin 1 receptor associated kinase 4	interleukin 1 receptor associated kinase 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Endosome Membrane Extrinsic Component Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Neutrophil Mediated Immunity MyD88-dependent Toll-like Receptor Signaling Pathway Signal Transduction JNK Cascade Toll Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Interleukin-1-mediated Signaling Pathway Neutrophil Migration	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Toll Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs		1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE Fostamatinib	Fostamatinib
Diseases		Defects of toll-like receptor signaling, including the following disease: Il-1 receptor-associated kinase 4 (IRAK-4) deficiency
GWAS		Immune reponse to smallpox (secreted TNF-alpha) ( 22610502) Inflammatory bowel disease ( 27569725)	Celiac disease ( 22057235) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24390342 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 19838195 26502338 26606652 26663301 33272962)
Interacting Genes		22 interacting genes: ARNT EIF4EBP1 H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 IKBKG IL36RN IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6 TRIM7 ZNF597	52 interacting genes: AKT1 BCL10 BTK CCDC47 FADD H3-4 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 OPTN PELI1 PELI2 PELI3 PPP1CC PPP3CB PRDX1 PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TBKBP1 TICAM2 TIFA TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 USP20 YTHDC2
Entrez ID		51135	3654
HPRD ID		06051	02235
Ensembl ID		ENSG00000198001	ENSG00000184216
Uniprot IDs		B2RAP9 B4E359 Q69FE3 Q9NWZ3	D3YTB5 P51617
PDB IDs		2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP 4RMZ 4U97 4U9A 4XS2 4Y73 4YO6 4YP8 4ZTL 4ZTM 4ZTN 5K72 5K75 5K76 5K7G 5K7I 5KX7 5KX8 5T1S 5T1T 5UIQ 5UIR 5UIS 5UIT 5UIU 5W84 5W85 6EG9 6EGA 6EGD 6EGE 6EGF 6F3D 6F3E 6F3G 6F3I 6LXY 6MOM 6N8G 6O8U 6O94 6O95 6O9D 6RFI 6RFJ 6THW 6THX 6THZ 6TI8 6TIA 6UYA 6VQL 7C2V 7C2W 7QG1 7QG2 7QG3 7QG5 8ATB 8ATL 8ATN 8BR5 8BR6 8BR7 8DKS 8SCE 8SCV 8SCW 8TVM 8TVN 8TX0 8UCB 8UCC 8V1O 8V2F 8V2L 8W3W 8W3X 8WTF	6BFN
Enriched GO Terms of Interacting Partners?		Chromosome Condensation Nucleosomal DNA Binding Negative Regulation Of DNA Recombination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA Recombination Chromatin DNA Binding Structural Constituent Of Chromatin Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Nucleosome Assembly Cell Surface Pattern Recognition Receptor Signaling Pathway Nucleosome Euchromatin Nucleosome Organization Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Toll Signaling Pathway Signaling Adaptor Activity Regulation Of Macromolecule Metabolic Process Innate Immune Response Response To Lipopolysaccharide Interleukin-33-mediated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Protein-DNA Complex Assembly Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Production Defense Response To Symbiont Defense Response To Other Organism Regulation Of Metabolic Process Regulation Of Cytokine Production Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Immune Response Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Chemokine Production Regulation Of DNA Metabolic Process Response To External Biotic Stimulus	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Signaling Pathway Immune System Process Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Defense Response Regulation Of Innate Immune Response Response To External Biotic Stimulus Cell Surface Toll-like Receptor Signaling Pathway Response To Other Organism Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Toll-like Receptor 4 Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Positive Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Immune Response Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cytokine Production Signal Transduction Intracellular Signaling Cassette Signaling Adaptor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Signaling Regulation Of Cell Communication
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