PELI2 and YTHDF2

Number of citations of the paper that reports this interaction (PubMedID 37452367)
48

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		PELI2	YTHDF2
Description		pellino E3 ubiquitin protein ligase family member 2	YTH N6-methyladenosine RNA binding protein F2
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GO Annotations	Cellular Component	Cytosol	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Centriolar Satellite Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	RNA Binding MRNA Binding Protein Binding C5-methylcytidine-containing RNA Reader Activity N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade	Oocyte Maturation Immune System Process MRNA Catabolic Process Humoral Immune Response Gamete Generation Spermatogenesis Spermatogonial Cell Division Cell Differentiation Regulation Of Cell Adhesion Stress Granule Assembly Regulation Of MRNA Stability Innate Immune Response Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Translational Initiation Oogenesis Embryonic Morphogenesis Regulation Of Neurogenesis Cell Division Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Organelle Assembly Hematopoietic Stem Cell Proliferation Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation Positive Regulation Of Cap-independent Translational Initiation Regulation Of RRNA Processing Negative Regulation Of Stem Cell Differentiation
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		44 interacting genes: BCL10 CEP170B CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 IRS1 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MPDZ MYD88 MYO10 NEK9 NUP62 OR7D2 PCGF2 PICALM PRR36 RABEP1 RBBP8 REL RMDN3 RNF220 SEPTIN3 SP4 SRPK1 TGM2 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4 YTHDF2	7 interacting genes: APP CREBBP OGT PELI2 PTEN SNCA STUB1
Entrez ID		57161	51441
HPRD ID		17835	06587
Ensembl ID		ENSG00000139946	ENSG00000198492
Uniprot IDs		Q9H716 Q9HAT8	Q9Y5A9
PDB IDs		3EGA 3EGB	4RDN 4RDO 4WQN 7A1V 7BIK 7R5F 7R5L 7R5W 7YWB 7YX6 7YXE 7Z26 7Z4U 7Z54 7Z5M 7Z7B 7Z7F 7Z8P 7Z8W 7Z8X 7Z92 7Z93 7ZG4
Enriched GO Terms of Interacting Partners?		Toll Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response-activating Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Activation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Adaptor Activity Anatomical Structure Morphogenesis Regulation Of Apoptotic Signaling Pathway Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Defense Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Response To Stress Regulation Of Cell Communication Cellular Developmental Process Regulation Of Signaling Regulation Of Gene Expression Positive Regulation Of DNA-binding Transcription Factor Activity	Positive Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Tau Protein Binding Regulation Of Cell Junction Assembly Regulation Of Toll Signaling Pathway Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Protein Stability Enzyme Binding Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Generation Of Precursor Metabolites And Energy Ubiquitin-ubiquitin Ligase Activity Adult Behavior Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neurotransmitter Uptake Regulation Of Synapse Assembly Positive Regulation Of Catabolic Process Cellular Response To Copper Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Histone Acetyltransferase Complex Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Locomotory Behavior Amyloid Fibril Formation Microglial Cell Activation Regulation Of Protein Modification Process Negative Regulation Of Signal Transduction Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Biological Quality Reproductive Behavior Leukocyte Activation Involved In Inflammatory Response Response To Copper Ion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Stabilization Synapse Organization Positive Regulation Of Response To Endoplasmic Reticulum Stress Rhythmic Process Positive Regulation Of Signal Transduction Neuron Projection Organization
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