PELI2 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 34674267)
0

Data Source:
BioGRID (two hybrid)

		PELI2	RBBP8
Description		pellino E3 ubiquitin protein ligase family member 2	RB binding protein 8, endonuclease
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GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Chromosome Transcription Repressor Complex Site Of Double-strand Break BRCA1-C Complex
	Molecular Function	Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Damaged DNA Binding Transcription Corepressor Activity Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of DNA-templated Transcription Cell Division Meiotic Cell Cycle DNA Strand Resection Involved In Replication Fork Processing
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Seckel syndrome
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)	Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 18391951 25429064) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		44 interacting genes: BCL10 CEP170B CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 IRS1 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MPDZ MYD88 MYO10 NEK9 NUP62 OR7D2 PCGF2 PICALM PRR36 RABEP1 RBBP8 REL RMDN3 RNF220 SEPTIN3 SP4 SRPK1 TGM2 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4 YTHDF2	40 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PELI2 PIAS4 PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 RNF4 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 UBE2I USP4
Entrez ID		57161	5932
HPRD ID		17835	04990
Ensembl ID		ENSG00000139946	ENSG00000101773
Uniprot IDs		Q9H716 Q9HAT8	Q99708
PDB IDs		3EGA 3EGB	1Y98 2L4Z 4D2H 7BGF
Enriched GO Terms of Interacting Partners?		Toll Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response-activating Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Activation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Adaptor Activity Anatomical Structure Morphogenesis Regulation Of Apoptotic Signaling Pathway Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Defense Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Response To Stress Regulation Of Cell Communication Cellular Developmental Process Regulation Of Signaling Regulation Of Gene Expression Positive Regulation Of DNA-binding Transcription Factor Activity	Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Post-translational Protein Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Protein Modification Process BRCA1-B Complex Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mitotic G2/M Transition Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Ubiquitination Mitotic G2 DNA Damage Checkpoint Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Homologous Recombination Nucleoplasm Regulation Of Apoptotic Signaling Pathway Protein Polyubiquitination DNA Strand Resection Involved In Replication Fork Processing
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