BAD and YWHAB

Number of citations of the paper that reports this interaction (PMID 9369453)
28

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		BAD	YWHAB
Gene Name		BCL2-associated agonist of cell death	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Transcriptional Repressor Complex Cytoplasmic Vesicle Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase 2B Binding Protein Kinase B Binding Protein Heterodimerization Activity	Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Protein Complex Binding Histone Deacetylase Binding Phosphoserine Binding Phosphoprotein Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Glucose Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Response To Estradiol Response To Progesterone Positive Regulation Of Glucokinase Activity Response To Testosterone Response To Oleic Acid Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway Response To Drug Response To Hydrogen Peroxide Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Type B Pancreatic Cell Proliferation Innate Immune Response Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Response To Calcium Ion Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Cellular Response To Chromate Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Protein Targeting Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Negative Regulation Of Protein Dephosphorylation Hippo Signaling Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Transcription, DNA-templated Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cytoplasmic Sequestering Of Protein Protein Heterooligomerization Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Activation of BH3-only proteins Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR NRAGE signals death through JNK Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF Regulation of mRNA stability by proteins that bind AU-rich elements DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR Programmed Cell Death NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Intrinsic Pathway for Apoptosis Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer Tristetraprolin (TTP) destabilizes mRNA NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation Signaling by Hippo RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs
Diseases
GWAS		Mean platelet volume ( 22423221) Sarcoidosis ( 22837380)
Protein-Protein Interactions		43 interactors: AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CREB3L3 EWSR1 HRK KEAP1 MAP2K5 MAPK8 MCL1 PAK1 PAK7 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	137 interactors: ABL1 ADAM22 AKAP13 ALS2 APP ATP5A1 BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EPB41 EPB41L1 EPB41L3 EXO1 FER FRMD6 GAPVD1 GEM HDAC5 HES1 HIST1H3A HSP90AB1 HSPA1A HSPA1B HSPA5 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLLT4 MLXIP MPRIP MST1R OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRPK2 SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		572	7529
HPRD ID		04409	03184
Ensembl ID		ENSG00000002330	ENSG00000166913
Uniprot IDs		Q92934	P31946
PDB IDs		1G5J	2BQ0 2C23 4DNK
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Regulation Of Cellular Localization Phosphorylation Regulation Of Cellular Process Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Localization Cellular Response To Stress Regulation Of Cellular Protein Metabolic Process Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Signal Transduction Cellular Response To Stimulus Cell Communication Phosphate-containing Compound Metabolic Process	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cell Communication Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Response To Organic Substance Cellular Response To Stimulus Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Signaling Protein Phosphorylation Cell Cycle Response To Growth Factor Response To Stimulus Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Process Neurotrophin Signaling Pathway Innate Immune Response Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Growth Factor Stimulus Phosphorylation Cellular Localization Cellular Response To Insulin Stimulus Anatomical Structure Development Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Immune System Process Regulation Of Metabolic Process
Tagcloud ?		androgen bak bax colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl	3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz
Tagcloud (Difference) ?		androgen bak bax colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl	3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz
Tagcloud (Intersection) ?