BAD and HRK

Number of citations of the paper that reports this interaction (PubMedID 11483855)
0

Data Source:
HPRD (two hybrid, in vitro)

		BAD	HRK
Description		BCL2 associated agonist of cell death	harakiri, BCL2 interacting protein
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane BAD-BCL-2 Complex	Mitochondrion Membrane
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Protein Kinase Binding Protein Phosphatase Binding Cysteine-type Endopeptidase Activator Activity	Protein Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Type B Pancreatic Cell Proliferation Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Type B Pancreatic Cell Development	Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Potassium Ion Starvation Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Navitoclax
Diseases
GWAS		Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Platelet count ( 22423221) Sarcoidosis ( 22837380) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alzheimer's disease (age of onset) ( 22005931) Brain morphology (MOSTest) ( 32665545) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Hippocampal volume ( 28098162 22504421) Presubiculum volume ( 30279459) Presubiculum volume (corrected for total hippocampal volume) ( 30279459) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)
Interacting Genes		46 interacting genes: ACTN2 AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CHEK1 CREB3L3 EWSR1 HRK KEAP1 KRT31 MAP2K5 MAPK8 MCL1 PAK1 PAK5 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1
Entrez ID		572	8739
HPRD ID		04409	04581
Ensembl ID		ENSG00000002330	ENSG00000135116
Uniprot IDs		Q92934	O00198
PDB IDs		1G5J 7Q16	2L58 2L5B 6XY4 7P0U
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Cytosol Apoptotic Process Programmed Cell Death Cell Death Protein Phosphorylation Response To Stress TORC1 Signaling Regulation Of Cellular Component Organization Signal Transduction Phosphorylation Protein Sequestering Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cytoplasm Cellular Response To Starvation TOR Signaling Cellular Response To Nutrient Levels Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Modification Process Response To Starvation Protein Domain Specific Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Phosphoserine Residue Binding Extrinsic Apoptotic Signaling Pathway Channel Activity Positive Regulation Of Programmed Cell Death Mitochondrial Outer Membrane Intracellular Signaling Cassette Bcl-2 Family Protein Complex Regulation Of Protein Localization Identical Protein Binding ATP Binding Intracellular Protein Localization Apoptotic Signaling Pathway	Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway Channel Activity Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Mitochondrion Organization Positive Regulation Of Programmed Cell Death BH3 Domain Binding Apoptotic Signaling Pathway DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Death Programmed Cell Death Negative Regulation Of Anoikis Intracellular Signal Transduction BAD-BCL-2 Complex Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Dendritic Cell Apoptotic Process Epithelial Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Cell Population Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Autophagy Mitochondrial Membrane Organization Regulation Of Autophagy Regulation Of Apoptotic Signaling Pathway Organelle Organization Mitochondrial Fusion Mitochondrion Hematopoietic Stem Cell Differentiation Programmed Cell Death Involved In Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Regulation Of Cellular Response To Stress
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