BAD and PIM3

Number of citations of the paper that reports this interaction (PubMedID 16403219)
52

Data Source:
HPRD (in vitro, in vivo)

		BAD	PIM3
Description		BCL2 associated agonist of cell death	Pim-3 proto-oncogene, serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane BAD-BCL-2 Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Protein Kinase Binding Protein Phosphatase Binding Cysteine-type Endopeptidase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Type B Pancreatic Cell Proliferation Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Type B Pancreatic Cell Development	Protein Phosphorylation Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Forskolin
Pathways		Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Navitoclax	Fostamatinib
Diseases
GWAS		Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Platelet count ( 22423221) Sarcoidosis ( 22837380) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Acne (severe) ( 24927181) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Cannabis dependence ( 21668797) Type 2 diabetes ( 29632382 30297969 32499647) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		46 interacting genes: ACTN2 AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CHEK1 CREB3L3 EWSR1 HRK KEAP1 KRT31 MAP2K5 MAPK8 MCL1 PAK1 PAK5 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	1 interacting genes: BAD
Entrez ID		572	415116
HPRD ID		04409	15137
Ensembl ID		ENSG00000002330	ENSG00000198355
Uniprot IDs		Q92934	Q86V86
PDB IDs		1G5J 7Q16
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Cytosol Apoptotic Process Programmed Cell Death Cell Death Protein Phosphorylation Response To Stress TORC1 Signaling Regulation Of Cellular Component Organization Signal Transduction Phosphorylation Protein Sequestering Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cytoplasm Cellular Response To Starvation TOR Signaling Cellular Response To Nutrient Levels Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Modification Process Response To Starvation Protein Domain Specific Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Phosphoserine Residue Binding Extrinsic Apoptotic Signaling Pathway Channel Activity Positive Regulation Of Programmed Cell Death Mitochondrial Outer Membrane Intracellular Signaling Cassette Bcl-2 Family Protein Complex Regulation Of Protein Localization Identical Protein Binding ATP Binding Intracellular Protein Localization Apoptotic Signaling Pathway	BAD-BCL-2 Complex Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Membrane Potential Regulation Of Type B Pancreatic Cell Development Cellular Response To Nicotine Positive Regulation Of Membrane Potential Cysteine-type Endopeptidase Activator Activity Regulation Of Cellular Response To Osmotic Stress Type B Pancreatic Cell Proliferation Regulation Of Response To Osmotic Stress Positive Regulation Of B Cell Differentiation Pore Complex Assembly Release Of Cytochrome C From Mitochondria Positive Regulation Of Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of B Cell Differentiation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Release Of Cytochrome C From Mitochondria Response To Nicotine Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation ADP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Apoptotic Mitochondrial Changes Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Cellular Response To Mechanical Stimulus Ribonucleoside Diphosphate Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Insulin Secretion Positive Regulation Of B Cell Activation Nucleoside Diphosphate Metabolic Process Protein Phosphatase Binding Regulation Of Mitochondrion Organization Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Carbohydrate Catabolic Process Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Phospholipid Binding Positive Regulation Of T Cell Differentiation Glucose Metabolic Process Positive Regulation Of Proteolysis Response To Mechanical Stimulus Epithelial Cell Proliferation Carbohydrate Homeostasis
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