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BAD and MCL1
Number of citations of the paper that reports this interaction (PubMedID
10579309
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
BAD
MCL1
Description
BCL2 associated agonist of cell death
MCL1 apoptosis regulator, BCL2 family member
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Membrane
BAD-BCL-2 Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Membrane
Bcl-2 Family Protein Complex
Molecular Function
Protein Binding
Phospholipid Binding
Lipid Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cysteine-type Endopeptidase Activator Activity
Protein Binding
Protein Transmembrane Transporter Activity
Channel Activity
Protein Heterodimerization Activity
BH Domain Binding
BH3 Domain Binding
Biological Process
Release Of Cytochrome C From Mitochondria
Glucose Catabolic Process
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Autophagy
Positive Regulation Of Mitochondrial Membrane Potential
Cytokine-mediated Signaling Pathway
Positive Regulation Of Insulin Secretion
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Glucose Homeostasis
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Type B Pancreatic Cell Proliferation
Positive Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Proteolysis
ADP Metabolic Process
ATP Metabolic Process
Regulation Of Mitochondrial Membrane Permeability
Pore Complex Assembly
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Lipid
Cellular Response To Hypoxia
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Type B Pancreatic Cell Development
Cell Fate Determination
Release Of Cytochrome C From Mitochondria
Apoptotic Process
DNA Damage Response
Mitochondrial Fusion
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Autophagy
Cellular Homeostasis
Cell Differentiation
Response To Cytokine
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Transmembrane Transport
Protein Transmembrane Transport
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Anoikis
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Activation of BAD and translocation to mitochondria
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
Signaling by ALK fusions and activated point mutants
Drugs
Navitoclax
Diseases
GWAS
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Platelet count (
22423221
)
Sarcoidosis (
22837380
)
Vitiligo (
27723757
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Blood protein levels (
30072576
)
Coffee consumption (
31959922
)
Coronary artery disease (
29212778
)
Eosinophil count (
27863252
)
FEV1 (
30804560
)
Lung function (FEV1) (
26635082
)
Lung function (FVC) (
26635082
30804560
)
Mean corpuscular hemoglobin (
32888494
)
Melanoma (
21983785
)
Monocyte count (
29403010
)
Multiple sclerosis (
31604244
)
Refractive error (
32231278
)
Rhegmatogenous retinal detachment (
23585552
)
Sum eosinophil basophil counts (
27863252
)
White matter hyperintensity volume (
33293549
)
White matter hyperintensity volume (adjusted for hypertension) (
33293549
)
White matter hyperintensity volume x hypertension interaction (2df) (
33293549
)
Interacting Genes
46 interacting genes:
ACTN2
AKT1
ARAF
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BRAF
CDKN1A
CHEK1
CREB3L3
EWSR1
HRK
KEAP1
KRT31
MAP2K5
MAPK8
MCL1
PAK1
PAK5
PIM1
PIM2
PIM3
PPP1CA
PPP3CA
PRDX2
PRKACA
PRKCI
RAF1
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA5
S100A10
SFN
SNCA
STEAP3
SUMO2
WASF1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
40 interacting genes:
APEX1
BAD
BAK1
BAX
BBC3
BCL2L1
BCL2L11
BID
BIK
BMF
BOK
BTRC
CASP3
CDC20
CHRM4
DAD1
FBXW11
GSK3A
GSK3B
HIF1A
HRK
HUWE1
KCNF1
MAPK1
MAPK10
PCNA
PIN1
PMAIP1
SIRT1
SIRT2
SIRT3
STX8
TNKS
TPT1
TRAF6
TRIM11
UBXN6
UHRF2
USP9X
VDAC1
Entrez ID
572
4170
HPRD ID
04409
08870
Ensembl ID
ENSG00000002330
ENSG00000143384
Uniprot IDs
Q92934
A0A087WT64
C8YZ26
Q07820
PDB IDs
1G5J
7Q16
2KBW
2MHS
2NL9
2NLA
2PQK
3D7V
3IO9
3KJ0
3KJ1
3KJ2
3KZ0
3MK8
3PK1
3TWU
3WIX
3WIY
4BPI
4BPJ
4HW2
4HW3
4HW4
4OQ5
4OQ6
4WGI
4WMR
4WMS
4WMT
4WMU
4WMV
4WMW
4WMX
4ZBF
4ZBI
5C3F
5C6H
5FC4
5FDO
5FDR
5IEZ
5IF4
5JSB
5KU9
5LOF
5MES
5MEV
5UUM
5VKC
5VX2
5W89
5W8F
6B4L
6B4U
6BW2
6BW8
6FS0
6FS1
6FS2
6MBD
6MBE
6NE5
6O4U
6O6F
6O6G
6OQB
6OQC
6OQD
6OQN
6OVC
6P3P
6QB3
6QB4
6QB6
6QFC
6QFI
6QFM
6QFQ
6QGD
6QXJ
6QYK
6QYL
6QYN
6QYO
6QYP
6QZ5
6QZ6
6QZ7
6QZ8
6QZB
6STJ
6U63
6U64
6U65
6U67
6U6F
6UA3
6UAB
6UD2
6UDI
6UDT
6UDU
6UDV
6UDX
6UDY
6VBX
6YBG
6YBJ
6YBK
6YBL
6ZIE
7NB4
7NB7
7XGE
8AV9
8EKX
8EL0
8EL1
8G3S
8G3T
8G3U
8G3W
8G3X
8G3Y
8H7B
8IQM
8QSO
8SVY
8T6F
8VJP
8Y1Y
8Y1Z
8Y20
9BCG
9CKN
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Protein Kinase Activity
Kinase Activity
Apoptotic Mitochondrial Changes
Release Of Cytochrome C From Mitochondria
Cytosol
Apoptotic Process
Programmed Cell Death
Cell Death
Protein Phosphorylation
Response To Stress
TORC1 Signaling
Regulation Of Cellular Component Organization
Signal Transduction
Phosphorylation
Protein Sequestering Activity
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cytoplasm
Cellular Response To Starvation
TOR Signaling
Cellular Response To Nutrient Levels
Mitochondrion Organization
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein Modification Process
Response To Starvation
Protein Domain Specific Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Protein Metabolic Process
Phosphoserine Residue Binding
Extrinsic Apoptotic Signaling Pathway
Channel Activity
Positive Regulation Of Programmed Cell Death
Mitochondrial Outer Membrane
Intracellular Signaling Cassette
Bcl-2 Family Protein Complex
Regulation Of Protein Localization
Identical Protein Binding
ATP Binding
Intracellular Protein Localization
Apoptotic Signaling Pathway
Regulation Of Mitochondrion Organization
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Mitochondrial Membrane Permeability
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Release Of Cytochrome C From Mitochondria
Apoptotic Mitochondrial Changes
Regulation Of Membrane Permeability
Regulation Of Apoptotic Process
Positive Regulation Of Organelle Organization
Regulation Of Programmed Cell Death
Regulation Of Organelle Organization
Cellular Response To Stress
Bcl-2 Family Protein Complex
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Apoptotic Signaling Pathway
Apoptotic Process
Programmed Cell Death
Cell Death
Mitochondrial Membrane Organization
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Membrane Permeability
Regulation Of Intrinsic Apoptotic Signaling Pathway
Mitochondrion Organization
Positive Regulation Of Membrane Permeability
DNA Damage Response
Mitochondrial Outer Membrane
Regulation Of Autophagy
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Intrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Cellular Response To Stress
Regulation Of Neuron Apoptotic Process
Mitochondrion
Leukocyte Apoptotic Process
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Response To Endoplasmic Reticulum Stress
Response To Stress
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Signal Transduction
Organelle Organization
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cellular Component Organization
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Tagcloud (Intersection)
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