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BAD and RPS6KA2
Number of citations of the paper that reports this interaction (PubMedID
12897128
)
42
Data Source:
HPRD
(in vivo, in vitro)
BAD
RPS6KA2
Description
BCL2 associated agonist of cell death
ribosomal protein S6 kinase A2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Membrane
BAD-BCL-2 Complex
Nucleus
Nucleoplasm
Cytoplasm
Spindle
Cytosol
Synapse
Meiotic Spindle
Molecular Function
Protein Binding
Phospholipid Binding
Lipid Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cysteine-type Endopeptidase Activator Activity
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Release Of Cytochrome C From Mitochondria
Glucose Catabolic Process
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Autophagy
Positive Regulation Of Mitochondrial Membrane Potential
Cytokine-mediated Signaling Pathway
Positive Regulation Of Insulin Secretion
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Glucose Homeostasis
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Type B Pancreatic Cell Proliferation
Positive Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Proteolysis
ADP Metabolic Process
ATP Metabolic Process
Regulation Of Mitochondrial Membrane Permeability
Pore Complex Assembly
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Lipid
Cellular Response To Hypoxia
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Positive Regulation Of Type B Pancreatic Cell Development
Oocyte Maturation
Brain Renin-angiotensin System
Signal Transduction
Chemical Synaptic Transmission
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Cardiac Muscle Cell Apoptotic Process
Intracellular Signal Transduction
TORC1 Signaling
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Meiotic Nuclear Division
Heart Contraction
Regulation Of Protein Processing
Cellular Response To Carbohydrate Stimulus
Pathways
Activation of BAD and translocation to mitochondria
Activation of BAD and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Navitoclax
Diseases
GWAS
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Platelet count (
22423221
)
Sarcoidosis (
22837380
)
Vitiligo (
27723757
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Alzheimer's disease progression score (
29860282
)
Bipolar disorder (
31043756
34002096
)
Bipolar I disorder (
31043756
)
Blood pressure (smoking interaction) (
25189868
)
Café-au-lait macule number in neurofibromatosis type1 (
32869517
)
Dental caries (
23259602
)
HDL cholesterol levels in HIV infection (
33109212
)
Inflammatory bowel disease (
23128233
27569725
)
Macrovascular complications in type 2 diabetes (
33430853
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Smooth-surface caries (
24556642
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Waist circumference (
28552196
)
Interacting Genes
46 interacting genes:
ACTN2
AKT1
ARAF
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BRAF
CDKN1A
CHEK1
CREB3L3
EWSR1
HRK
KEAP1
KRT31
MAP2K5
MAPK8
MCL1
PAK1
PAK5
PIM1
PIM2
PIM3
PPP1CA
PPP3CA
PRDX2
PRKACA
PRKCI
RAF1
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA5
S100A10
SFN
SNCA
STEAP3
SUMO2
WASF1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
12 interacting genes:
BAD
CREB1
FLNC
FOS
JUN
L1CAM
MAGI1
MAP2K1
MAPK1
MAPK3
SHANK1
TP53
Entrez ID
572
6196
HPRD ID
04409
03403
Ensembl ID
ENSG00000002330
ENSG00000071242
Uniprot IDs
Q92934
B7Z3B5
F2Z2J1
Q15349
X5D337
PDB IDs
1G5J
7Q16
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Protein Kinase Activity
Kinase Activity
Apoptotic Mitochondrial Changes
Release Of Cytochrome C From Mitochondria
Cytosol
Apoptotic Process
Programmed Cell Death
Cell Death
Protein Phosphorylation
Response To Stress
TORC1 Signaling
Regulation Of Cellular Component Organization
Signal Transduction
Phosphorylation
Protein Sequestering Activity
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Cytoplasm
Cellular Response To Starvation
TOR Signaling
Cellular Response To Nutrient Levels
Mitochondrion Organization
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein Modification Process
Response To Starvation
Protein Domain Specific Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Protein Metabolic Process
Phosphoserine Residue Binding
Extrinsic Apoptotic Signaling Pathway
Channel Activity
Positive Regulation Of Programmed Cell Death
Mitochondrial Outer Membrane
Intracellular Signaling Cassette
Bcl-2 Family Protein Complex
Regulation Of Protein Localization
Identical Protein Binding
ATP Binding
Intracellular Protein Localization
Apoptotic Signaling Pathway
Regulation Of Golgi Inheritance
Trachea Formation
ERBB3 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Bergmann Glial Cell Differentiation
Regulation Of Golgi Organization
Regulation Of Early Endosome To Late Endosome Transport
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Face Development
Schwann Cell Development
Animal Organ Formation
ERBB2 Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Interleukin-34-mediated Signaling Pathway
Hematopoietic Or Lymphoid Organ Development
Lung Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Thyroid Gland Development
Astrocyte Differentiation
Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Developmental Process
Regulation Of Stress-activated MAPK Cascade
Cell Differentiation
Gland Development
Anatomical Structure Morphogenesis
Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Multicellular Organismal Process
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Caveolin-mediated Endocytosis
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Cellular Component Organization
Response To Lipid
Cell Surface Receptor Signaling Pathway
Response To Nicotine
Transcription Factor AP-1 Complex
Regulation Of Cell Development
Thymus Development
Intracellular Signaling Cassette
Cardiac Neural Crest Cell Development Involved In Heart Development
Response To Epidermal Growth Factor
ERK1 And ERK2 Cascade
Positive Regulation Of MiRNA Transcription
Outer Ear Morphogenesis
Identical Protein Binding
Cellular Response To Starvation
Positive Regulation Of MiRNA Metabolic Process
Glial Cell Development
Response To Mechanical Stimulus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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