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EXOSC1
Gene Name
exosome component 1
Image
Gene Ontology Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Molecular Function
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-protein Interactions
21 interactors:
A2M
APP
CDC37
ECSIT
EXOC6
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
KCTD1
MAST1
NOS3
NUP160
PAK7
REL
RNF32
TCF4
UPF2
XRN1
Entrez ID
51013
HPRD ID
16223
Ensembl ID
Uniprot IDs
Q9Y3B2
PDB IDs
2NN6
Enriched GO Terms of Interacting Partners
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Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
RRNA Metabolic Process
MRNA Metabolic Process
RRNA Processing
Aromatic Compound Catabolic Process
Ribosome Biogenesis
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear MRNA Surveillance
DNA Deamination
RNA Surveillance
NcRNA Metabolic Process
RNA Metabolic Process
Ribonucleoprotein Complex Biogenesis
Cellular Macromolecule Catabolic Process
Gene Expression
RNA Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Metabolic Process
Histone MRNA Catabolic Process
RRNA Catabolic Process
DNA Modification
Establishment Of Localization In Cell
Histone MRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Immune System Process
Cellular Localization
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Nucleocytoplasmic Transport
Nuclear Transport
Regulation Of Growth
MRNA Export From Nucleus
Platelet Degranulation
Smooth Muscle Hyperplasia
Synaptic Growth At Neuromuscular Junction
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Complement Activation, Lectin Pathway
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