EXOSC1 and EXOSC8

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		EXOSC1	EXOSC8
Gene Name		exosome component 1	exosome component 8
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Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Binding Exoribonuclease Activity Protein Binding	Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Biological_process Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: A2M APP CDC37 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KCTD1 MAST1 NOS3 NUP160 PAK7 REL RNF32 TCF4 UPF2 XRN1	42 interactors: AEN ATF2 COL23A1 COX5A CRMP1 CWC22 DIS3 DUSP23 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM90A1 FHOD1 FOXN3 FRG1 LSM1 LSM7 MKRN1 MORN4 MPP6 OTUD4 RASSF1 REL RPP14 SKIV2L2 SNRPC TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP6 XRN1 XRN2 ZFP36
Entrez ID		51013	11340
HPRD ID		16223	09351
Ensembl ID			ENSG00000120699
Uniprot IDs		Q9Y3B2	Q96B26
PDB IDs		2NN6	2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process MRNA Metabolic Process RRNA Processing Aromatic Compound Catabolic Process Ribosome Biogenesis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Nuclear MRNA Surveillance DNA Deamination RNA Surveillance NcRNA Metabolic Process RNA Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Macromolecule Catabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Histone MRNA Catabolic Process RRNA Catabolic Process DNA Modification Establishment Of Localization In Cell Histone MRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Immune System Process Cellular Localization Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Nucleocytoplasmic Transport Nuclear Transport Regulation Of Growth MRNA Export From Nucleus Platelet Degranulation Smooth Muscle Hyperplasia Synaptic Growth At Neuromuscular Junction Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Complement Activation, Lectin Pathway	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Metabolic Process RRNA Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Ribosome Biogenesis Aromatic Compound Catabolic Process Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis RNA Metabolic Process Cellular Macromolecule Catabolic Process NcRNA Metabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis RRNA Catabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Maturation Of 5.8S RRNA Gene Expression Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process DNA Deamination Histone MRNA Catabolic Process RNA Processing Cellular Metabolic Process Histone MRNA Metabolic Process MRNA Processing Intracellular MRNA Localization Metabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' DNA Modification Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Splicing SnoRNA Metabolic Process RNA Splicing, Via Transesterification Reactions
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