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EXOSC1 and XRN1
Number of citations of the paper that reports this interaction (PubMedID
15231747
)
47
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
EXOSC1
XRN1
Description
exosome component 1
5'-3' exoribonuclease 1
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nucleolar Exosome (RNase Complex)
P-body
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Molecular Function
Nucleic Acid Binding
RNA Binding
RNA Exonuclease Activity
Protein Binding
G-quadruplex RNA Binding
Nucleic Acid Binding
DNA Binding
RNA Binding
Nuclease Activity
Exonuclease Activity
5'-3' RNA Exonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
Hydrolase Activity
G-quadruplex DNA Binding
Telomerase RNA Binding
Biological Process
RRNA Processing
RNA Processing
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
RNA Metabolic Process
RRNA Catabolic Process
Negative Regulation Of Translation
Negative Regulation Of Telomere Maintenance Via Telomerase
Response To Testosterone
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Cellular Response To Cycloheximide
Cellular Response To Puromycin
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Nuclear RNA decay
mRNA decay by 5' to 3' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Early spontaneous preterm birth (
31194736
)
Spontaneous preterm birth with premature rupture of membranes (
31194736
)
Benign childhood epilepsy with centro-temporal spikes (
32580138
)
Birth weight (
31043758
)
Caffeine consumption from coffee or tea (
33287642
)
Heel bone mineral density (
30598549
)
Mean spheric corpuscular volume (
32888494
)
Mosquito bite size (
28199695
)
Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) (
33987465
)
Waist-hip ratio (
28552196
)
Interacting Genes
36 interacting genes:
A2M
APP
ASB9
CDC37
CPSF7
DDIT4L
DMRTB1
ECSIT
EXOC6
EXOSC4
EXOSC5
EXOSC7
EXOSC8
EXOSC9
FHL3
KCTD1
LNX1
LSM3
MAST1
NOS3
NUP160
PAK5
PRRC2B
PTEN
RBPMS
REL
RNF32
SF1
SH3GLB2
TCF4
TEX11
UPF2
WDR83
XRN1
ZNF143
ZNF76
67 interacting genes:
ADGRE5
ALDOA
ANGPTL6
AP1G2
ATP5MC2
B3GALT6
BAG6
C1GALT1
CBX5
CCT5
CENPBD1P
CHD4
CTSB
CTSH
DCP1B
DNASE2
DPP7
DXO
EXOSC1
EXOSC10
EXOSC6
EXOSC8
FADS1
FBXO7
GLMP
HEATR1
HERC2P4
HNRNPA1
KATNB1
LDHA
LEPR
LGALS3BP
LINC01541
LSM4
MAN2C1
MIR34C
MIR429
MIR7-1
MTCH2
MTREX
NDUFA13
NDUFB10
NDUFB9
PABPC4
PLEKHG2
POLD2
PPP2CA
PRADC1
PSMB5
RBMX
RNF10
RNF187
SDHB
SKIC2
SLC61A1
SMARCD2
SNHG1
SPATA20
SRRM2
STAM2
TMEM50A
UPF1
UPF2
UPF3B
VWA5B2
WAPL
ZFP36
Entrez ID
51013
54464
HPRD ID
16223
10470
Ensembl ID
ENSG00000171311
ENSG00000114127
Uniprot IDs
B1AMU3
Q9Y3B2
Q8IZH2
PDB IDs
2NN6
6D6Q
6D6R
6H25
9G8M
9G8N
9G8O
9G8P
Enriched GO Terms of Interacting Partners
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Nuclear MRNA Surveillance
Exoribonuclease Complex
RRNA Catabolic Process
U4 SnRNA 3'-end Processing
Nucleolar Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
RNA Exonuclease Activity
Nuclear RNA Surveillance
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
RNA Surveillance
SnRNA 3'-end Processing
Nuclear-transcribed MRNA Catabolic Process
U5 SnRNA 3'-end Processing
U1 SnRNA 3'-end Processing
SnRNA Processing
MRNA Catabolic Process
RNA 3'-end Processing
MRNA Metabolic Process
SnRNA Metabolic Process
RNA Catabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
TRNA Surveillance
TRAMP-dependent TRNA Surveillance Pathway
Nuclear Polyadenylation-dependent RRNA Catabolic Process
MRNA 3'-UTR AU-rich Region Binding
3'-5'-RNA Exonuclease Activity
RRNA 3'-end Processing
TRNA Decay
Nucleobase-containing Compound Catabolic Process
RNA Processing
RRNA Metabolic Process
RNA Binding
RRNA Processing
Nucleus
RNA Metabolic Process
Poly(A)-dependent SnoRNA 3'-end Processing
Protein Binding
Macromolecule Catabolic Process
Negative Regulation Of Smooth Muscle Cell Proliferation
DNA Deamination
Negative Regulation Of Gene Expression
Histone MRNA Catabolic Process
Synapse Maturation
Nucleic Acid Metabolic Process
Sno(s)RNA Metabolic Process
Cytosol
Regulation Of Gene Expression
P-body
Histone MRNA Metabolic Process
Nucleobase-containing Compound Catabolic Process
RNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
Macromolecule Catabolic Process
Exosome (RNase Complex)
Catabolic Process
Nuclear Exosome (RNase Complex)
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
MRNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Nucleolar Exosome (RNase Complex)
Nuclear MRNA Surveillance
Cytoplasmic Exosome (RNase Complex)
RNA Exonuclease Activity
Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Nuclear RNA Surveillance
RNA Surveillance
ATP Biosynthetic Process
RNA Metabolic Process
Negative Regulation Of Gene Expression
Nucleoside Triphosphate Biosynthetic Process
ATP Metabolic Process
Positive Regulation Of MRNA Splicing, Via Spliceosome
Nucleic Acid Metabolic Process
Proton Motive Force-driven ATP Synthesis
MRNA 3'-UTR Binding
Purine Ribonucleotide Biosynthetic Process
RNA Binding
Positive Regulation Of RNA Splicing
Generation Of Precursor Metabolites And Energy
Ribose Phosphate Biosynthetic Process
Supraspliceosomal Complex
SnRNA Metabolic Process
Purine Nucleotide Biosynthetic Process
MRNA Binding
Exon-exon Junction Complex
Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of Metabolic Process
Proton Motive Force-driven Mitochondrial ATP Synthesis
Energy Derivation By Oxidation Of Organic Compounds
RNA Processing
Purine Ribonucleotide Metabolic Process
Nucleotide Biosynthetic Process
MRNA Transport
SnRNA Catabolic Process
Ribonucleotide Metabolic Process
Regulation Of MRNA Processing
RRNA Processing
Ribose Phosphate Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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