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EXOSC1 and CDC37
Number of citations of the paper that reports this interaction (PMID
21163940
)
13
Data Source:
BioGRID
(two hybrid)
EXOSC1
CDC37
Gene Name
exosome component 1
cell division cycle 37
Image
Gene Ontology Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cytoplasm
Cytosol
Ruffle Membrane
Protein Complex
Extracellular Vesicular Exosome
Molecular Function
RNA Binding
Exoribonuclease Activity
Protein Binding
Protein Binding
Kinase Binding
Heat Shock Protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Protein Kinase B Binding
Unfolded Protein Binding
Chaperone Binding
Hsp90 Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RRNA Processing
Gene Expression
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Folding
Protein Targeting
Protein Stabilization
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways
Regulation of mRNA stability by proteins that bind AU-rich elements
KSRP destabilizes mRNA
mRNA decay by 3' to 5' exoribonuclease
ATF4 activates genes
Tristetraprolin (TTP) destabilizes mRNA
PERK regulates gene expression
Unfolded Protein Response (UPR)
Deadenylation-dependent mRNA decay
Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by EGFRvIII in Cancer
Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS
Multiple sclerosis (
21833088
)
Protein-Protein Interactions
21 interactors:
A2M
APP
CDC37
ECSIT
EXOC6
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
KCTD1
MAST1
NOS3
NUP160
PAK7
REL
RNF32
TCF4
UPF2
XRN1
72 interactors:
A2M
APOE
APP
AR
BTBD10
C19orf44
CC2D1A
CDC37L1
CDK2
CDK3
CDK4
CDK5
CDK6
CDK7
CHGA
CHUK
CKS1B
CKS2
CRYM
CSNK2A1
CSNK2A2
CYP2C9
DCTN1
DEAF1
ECSIT
EIF2AK1
ELAVL3
EXOSC1
FBXL12
FBXW4
GCDH
GCH1
HSP90AA1
IFIT3
IFIT5
IKBKB
IKBKE
IKBKG
IMMT
LONP1
LOXL4
LUC7L2
MAP3K14
MAP3K3
MGEA5
MTOR
MZT2B
NCOA5
NOS3
NR2C2
PPHLN1
PRAM1
PRDX2
PRMT1
PSME1
RAD23A
RNF32
RPS15A
SAFB
SNX5
SPTBN4
SQSTM1
SRC
STAMBPL1
STIP1
STK11
TBK1
UBE2I
ZNF205
ZNF235
ZNF266
ZNF667
Entrez ID
51013
11140
HPRD ID
16223
05456
Ensembl ID
ENSG00000105401
Uniprot IDs
Q9Y3B2
Q16543
PDB IDs
2NN6
1US7
2K5B
2W0G
Enriched GO Terms of Interacting Partners
?
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
RRNA Metabolic Process
MRNA Metabolic Process
RRNA Processing
Aromatic Compound Catabolic Process
Ribosome Biogenesis
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Nuclear MRNA Surveillance
DNA Deamination
RNA Surveillance
NcRNA Metabolic Process
RNA Metabolic Process
Ribonucleoprotein Complex Biogenesis
Cellular Macromolecule Catabolic Process
Gene Expression
RNA Phosphodiester Bond Hydrolysis
Cellular Nitrogen Compound Metabolic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Catabolic Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Metabolic Process
Histone MRNA Catabolic Process
RRNA Catabolic Process
DNA Modification
Establishment Of Localization In Cell
Histone MRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Immune System Process
Cellular Localization
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Signaling Pathway
Nucleocytoplasmic Transport
Nuclear Transport
Regulation Of Growth
MRNA Export From Nucleus
Platelet Degranulation
Smooth Muscle Hyperplasia
Synaptic Growth At Neuromuscular Junction
Catenin Import Into Nucleus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Complement Activation, Lectin Pathway
Regulation Of Cellular Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Protein Phosphorylation
Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Response To Stress
Cellular Metabolic Process
Response To External Stimulus
Phosphorylation
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Protein Kinase Activity
I-kappaB Kinase/NF-kappaB Signaling
Response To Stimulus
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Mitotic Cell Cycle Phase Transition
Response To Virus
Cell Cycle Phase Transition
Catabolic Process
Regulation Of Catalytic Activity
Intracellular Receptor Signaling Pathway
Cell Cycle
Regulation Of Gene Expression
Positive Regulation Of Protein Metabolic Process
Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Cellular Protein Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Process
Phosphate-containing Compound Metabolic Process
Cellular Protein Modification Process
Cell Cycle Process
Regulation Of Signal Transduction
Protein Catabolic Process
Mitotic Cell Cycle
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Signaling
Toll-like Receptor 3 Signaling Pathway
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Cellular Response To Stimulus
Tagcloud
?
base
chick
clusters
conforms
consensus
copies
emphasize
exons
finger
flanking
gctat
ggg
glycosaminoglycans
homeodomain
hsp90
introns
kilobases
mzf1
pair
presumptive
promotion
reorganization
repetitive
s8
sizes
sp1
stabilization
striking
tatgggga
Tagcloud (Difference)
?
base
chick
clusters
conforms
consensus
copies
emphasize
exons
finger
flanking
gctat
ggg
glycosaminoglycans
homeodomain
hsp90
introns
kilobases
mzf1
pair
presumptive
promotion
reorganization
repetitive
s8
sizes
sp1
stabilization
striking
tatgggga
Tagcloud (Intersection)
?