EXOSC1 and EXOSC4

Number of citations of the paper that reports this interaction (PMID 11719186)
268

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo, two hybrid)

		EXOSC1	EXOSC4
Gene Name		exosome component 1	exosome component 4
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Gene Ontology Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	RNA Binding Exoribonuclease Activity Protein Binding	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding AU-rich Element Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing Gene Expression Positive Regulation Of Cell Growth Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: A2M APP CDC37 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 KCTD1 MAST1 NOS3 NUP160 PAK7 REL RNF32 TCF4 UPF2 XRN1	27 interactors: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LRRC8D MPP6 MPZL1 NEK1 SKIV2L SKIV2L2 SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		51013	54512
HPRD ID		16223	16221
Ensembl ID			ENSG00000178896
Uniprot IDs		Q9Y3B2	Q9NPD3
PDB IDs		2NN6	2NN6
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process MRNA Metabolic Process RRNA Processing Aromatic Compound Catabolic Process Ribosome Biogenesis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Nuclear MRNA Surveillance DNA Deamination RNA Surveillance NcRNA Metabolic Process RNA Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Macromolecule Catabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Metabolic Process Histone MRNA Catabolic Process RRNA Catabolic Process DNA Modification Establishment Of Localization In Cell Histone MRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Immune System Process Cellular Localization Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Nucleocytoplasmic Transport Nuclear Transport Regulation Of Growth MRNA Export From Nucleus Platelet Degranulation Smooth Muscle Hyperplasia Synaptic Growth At Neuromuscular Junction Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Complement Activation, Lectin Pathway	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Processing Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear MRNA Surveillance Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecule Catabolic Process RNA Surveillance RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Catabolic Process Maturation Of 5.8S RRNA RNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing RNA Processing TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing DNA Deamination Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome MRNA Export From Nucleus Metabolic Process
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