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CCDC47 and IRAK1
Number of citations of the paper that reports this interaction (PMID
21903422
)
33
Data Source:
BioGRID
(affinity chromatography technology, pull down)
CCDC47
IRAK1
Gene Name
coiled-coil domain containing 47
interleukin-1 receptor-associated kinase 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Membrane
Integral Component Of Membrane
Nucleus
Cytoplasm
Lipid Particle
Cytosol
Plasma Membrane
Endosome Membrane
Interleukin-1 Receptor Complex
Molecular Function
Calcium Ion Binding
Protein Binding
Poly(A) RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Ubiquitin-protein Transferase Activity
Interleukin-1 Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Heat Shock Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Biological Process
Osteoblast Differentiation
ER Overload Response
Post-embryonic Development
Calcium Ion Homeostasis
Activation Of MAPK Activity
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Signal Transduction
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Aging
Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Peptidoglycan
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To Heat
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Oligomerization
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Hypoxia
Pathways
NF-kB is activated and signals survival
p75NTR recruits signalling complexes
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
IRAK1 recruits IKK complex
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
p75NTR signals via NF-kB
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
IRAK1 recruits IKK complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
Signalling by NGF
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
Cytokine Signaling in Immune system
p75 NTR receptor-mediated signalling
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions
7 interactors:
IRAK1
IRF7
RPL7A
SARM1
TIRAP
TMEM173
TOM1L1
49 interactors:
AKT1
BCL10
BTK
CCDC47
FADD
HIST3H3
HRAS
HSP90AA1
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JUN
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NTRK3
PELI1
PELI2
PELI3
PPP3CB
PRKCI
PRKCZ
RIPK2
SIGIRR
SQSTM1
STAT3
SUMO1
TAB2
TICAM2
TIFA
TIRAP
TLR2
TLR4
TMEM173
TOLLIP
TRAF4
TRAF6
TRIM32
UNC93B1
YTHDC2
Entrez ID
57003
3654
HPRD ID
17041
02235
Ensembl ID
ENSG00000108588
ENSG00000184216
Uniprot IDs
Q96A33
D3YTB5
P51617
PDB IDs
Enriched GO Terms of Interacting Partners
?
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Interferon-beta Production
Positive Regulation Of Immune Response
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Regulation Of Type I Interferon Production
Immune Response-regulating Signaling Pathway
Type I Interferon Production
Immune Response
Regulation Of Immune System Process
Defense Response
Response To Other Organism
Response To Biotic Stimulus
Regulation Of Toll-like Receptor Signaling Pathway
Regulation Of Interferon-beta Production
Immune System Process
Positive Regulation Of Cytokine Production
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein Binding
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Cellular Response To Cytokine Stimulus
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Binding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
MDA-5 Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Cytokine Production
Toll-like Receptor Signaling Pathway
Activation Of Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Regulation Of Innate Immune Response
Defense Response
Innate Immune Response
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
MyD88-dependent Toll-like Receptor Signaling Pathway
Immune Response
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Immune System Process
Immune System Process
Positive Regulation Of Immune Response
Positive Regulation Of Immune System Process
Toll-like Receptor 9 Signaling Pathway
Response To Stress
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cytokine Production
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor 5 Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor 10 Signaling Pathway
Signaling
Signal Transduction
Response To Organic Substance
Cell Communication
Positive Regulation Of Signal Transduction
Response To Biotic Stimulus
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cytokine Production
Response To Other Organism
Response To Stimulus
Positive Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Cellular Response To Stimulus
Regulation Of Signaling
Regulation Of Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Tagcloud
?
auc
autoimmunity
cancerous
clinicopathological
curve
curves
distinguish
embedded
fixed
formalin
herein
lung
lymph
metastasis
microarrays
node
nsclc
operating
paraffin
receiver
roc
sclc
spearman
stream
tlr
tnm
toll
unclarified
valuable
Tagcloud (Difference)
?
auc
autoimmunity
cancerous
clinicopathological
curve
curves
distinguish
embedded
fixed
formalin
herein
lung
lymph
metastasis
microarrays
node
nsclc
operating
paraffin
receiver
roc
sclc
spearman
stream
tlr
tnm
toll
unclarified
valuable
Tagcloud (Intersection)
?