CCDC47 and TOM1L1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CCDC47	TOM1L1
Description		coiled-coil domain containing 47	target of myb1 like 1 membrane trafficking protein
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Protein Folding Chaperone Complex Multi-pass Translocon Complex	Cytoplasm Lysosome Endosome Golgi Apparatus Golgi Stack Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Ribosome Binding Protein Folding Chaperone	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Osteoblast Differentiation Protein Folding ER Overload Response Endoplasmic Reticulum Organization Post-embryonic Development Endoplasmic Reticulum Calcium Ion Homeostasis ERAD Pathway Protein Insertion Into ER Membrane Calcium Ion Homeostasis Multi-pass Transmembrane Protein Insertion Into ER Membrane	Signal Transduction Protein Transport Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process
Pathways
Drugs
Diseases
GWAS			Carotid intima media thickness x smoking interaction ( 32117412) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Systolic blood pressure ( 34074324) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		9 interacting genes: IRAK1 IRF7 OGT PTEN RPL7A SARM1 STING1 TIRAP TOM1L1	29 interacting genes: AMFR CCDC47 CELF1 COPS7A CWF19L1 DNAJB13 FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TASOR TOLLIP TSG101 TUBA1B UBC UBXN4 VAV2 VCP
Entrez ID		57003	10040
HPRD ID		17041	05266
Ensembl ID		ENSG00000108588	ENSG00000141198
Uniprot IDs		Q96A33	O75674
PDB IDs		6W6L	3RRU
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Interferon-beta Production Innate Immune Response Signaling Adaptor Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Innate Immune Response Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Immune Response-activating Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Defense Response Cytosol Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Defense Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Signal Transduction Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Immune Response Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Response To Stress Intracellular Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway Response To External Biotic Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling	BAT3 Complex Binding ERAD Pathway Proteolysis Involved In Protein Catabolic Process Cytosol Ubiquitin Binding Response To Endoplasmic Reticulum Stress Neurotrophin TRKA Receptor Binding Endosome Transport Via Multivesicular Body Sorting Pathway Intracellular Signaling Cassette Derlin-1 Retrotranslocation Complex Phosphotyrosine Residue Binding Multivesicular Body Sorting Pathway Intracellular Signal Transduction Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Ubiquitin Protein Ligase Binding SUMO Binding Catabolic Process Insulin Receptor Substrate Binding Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Phosphatidylinositol 3-kinase Binding Ubiquitin-specific Protease Binding Regulation Of Exosomal Secretion Protein-folding Chaperone Binding Macromolecule Metabolic Process Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Modification Process Cell Activation Protein Phosphatase Binding RNA Binding Regulation Of Post-translational Protein Modification Fc Receptor Mediated Stimulatory Signaling Pathway Ubiquitin-like Protein Ligase Binding Protein Binding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endoplasmic Reticulum Membrane Proteasomal Protein Catabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen Epidermal Growth Factor Receptor Binding COP9 Signalosome Positive Regulation Of Cellular Component Biogenesis
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