CCDC47 and SARM1

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CCDC47	SARM1
Gene Name		coiled-coil domain containing 47	sterile alpha and TIR motif containing 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Cytoplasm Mitochondrion Cytosol Microtubule Cell Junction Axon Dendrite Extrinsic Component Of Mitochondrial Outer Membrane Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Osteoblast Differentiation ER Overload Response Post-embryonic Development Calcium Ion Homeostasis	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Glucose Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Dendrite Morphogenesis Regulation Of Neuron Death
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: IRAK1 IRF7 RPL7A SARM1 TIRAP TMEM173 TOM1L1	7 interactors: CCDC47 GHITM IRAK2 MYD88 NLRX1 STT3A TICAM2
Entrez ID		57003	23098
HPRD ID		17041	09664
Ensembl ID		ENSG00000108588	ENSG00000004139
Uniprot IDs		Q96A33	Q05B42 Q0D2N8 Q6SZW1
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Interferon-beta Production Positive Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Type I Interferon Production Immune Response Regulation Of Immune System Process Defense Response Response To Other Organism Response To Biotic Stimulus Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Interferon-beta Production Immune System Process Positive Regulation Of Cytokine Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Binding MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Cellular Response To Cytokine Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cytokine Production	Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Biotic Stimulus Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Chemokine Production Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Chemokine Production I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipid Inflammatory Response Immune Response-regulating Signaling Pathway Response To Interleukin-1 Immune Response Regulation Of Immune System Process JNK Cascade Response To Bacterium Positive Regulation Of Interleukin-18-mediated Signaling Pathway Defense Response Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Co-translational Protein Modification Positive Regulation Of Immune Response
Tagcloud ?			affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic tlr toll
Tagcloud (Difference) ?			affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic tlr toll
Tagcloud (Intersection) ?