CCDC47 and TMEM173

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		CCDC47	TMEM173
Gene Name		coiled-coil domain containing 47	transmembrane protein 173
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Poly(A) RNA Binding	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding
	Biological Process	Osteoblast Differentiation ER Overload Response Post-embryonic Development Calcium Ion Homeostasis	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Positive Regulation Of Transcription Factor Import Into Nucleus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Exogenous DsRNA
Pathways			Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		7 interactors: IRAK1 IRF7 RPL7A SARM1 TIRAP TMEM173 TOM1L1	9 interactors: CCDC47 DDOST IRAK1 LTN1 MBOAT7 SGPL1 STT3A SURF4 TRIM32
Entrez ID		57003	340061
HPRD ID		17041	14173
Ensembl ID		ENSG00000108588
Uniprot IDs		Q96A33	Q86WV6
PDB IDs			4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI
Enriched GO Terms of Interacting Partners?		Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Interferon-beta Production Positive Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Type I Interferon Production Immune Response Regulation Of Immune System Process Defense Response Response To Other Organism Response To Biotic Stimulus Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Interferon-beta Production Immune System Process Positive Regulation Of Cytokine Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Binding MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Cellular Response To Cytokine Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cytokine Production
Tagcloud ?			advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish
Tagcloud (Difference) ?			advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish
Tagcloud (Intersection) ?