CHPT1 and LTB4R2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHPT1	LTB4R2
Description		choline phosphotransferase 1	leukotriene B4 receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Endomembrane System Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Plasma Membrane Membrane
	Molecular Function	Diacylglycerol Cholinephosphotransferase Activity Protein Binding Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Diacylglycerol Binding Metal Ion Binding	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Regulation Of Cell Growth Lipid Metabolic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Platelet Activating Factor Biosynthetic Process Phospholipid Biosynthetic Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway
Pathways		Synthesis of PC	Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Leukotriene B4
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Orofacial clefts ( 33137956) Vitamin C levels ( 33203707)	Anorectal malformation ( 31136621) Height ( 28552196)
Interacting Genes		4 interacting genes: DRD2 HTR2B LTB4R2 TLCD4	46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B
Entrez ID		56994	56413
HPRD ID		13052	16153
Ensembl ID		ENSG00000111666	ENSG00000213906
Uniprot IDs		Q8WUD6	B4E292 Q9NPC1
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Alpha-subunit Binding Release Of Sequestered Calcium Ion Into Cytosol Smooth Muscle Contraction G Protein-coupled Receptor Activity Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Behavior Calcium Ion Transmembrane Import Into Cytosol Positive Regulation Of Cell Division Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium Ion Transmembrane Transport Chemical Homeostasis Negative Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Division Cell Migration Negative Regulation Of Dopamine Secretion Calcium Ion Homeostasis Muscle Contraction Intracellular Calcium Ion Homeostasis Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cell Motility Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Ameboidal-type Cell Migration Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Calcium Ion Transport Positive Regulation Of Neurotransmitter Uptake Muscle System Process Regulation Of Locomotion Involved In Locomotory Behavior	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B
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