STAT5A and UGT2B4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		STAT5A	UGT2B4
Gene Name		signal transducer and activator of transcription 5A	UDP glucuronosyltransferase 2 family, polypeptide B4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding	Retinoic Acid Binding Glucuronosyltransferase Activity
	Biological Process	Allantoin Metabolic Process Luteinization Natural Killer Cell Differentiation Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process JAK-STAT Cascade Female Pregnancy Lactation Peptidyl-tyrosine Phosphorylation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Positive Regulation Of Natural Killer Cell Differentiation Negative Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Positive Regulation Of Mast Cell Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Mammary Gland Epithelium Development Positive Regulation Of Mast Cell Proliferation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus	Estrogen Catabolic Process Xenobiotic Metabolic Process Metabolic Process Flavonoid Biosynthetic Process Cellular Response To Hormone Stimulus Cellular Glucuronidation Flavonoid Glucuronidation
Pathways		Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		72 interactors: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK LEF1 MAGEA12 MAPK1 MAPK3 MRPS6 NARF NCOR2 NLK NMI NR3C1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TSLP TXNDC11 UGT2B4 WASH2P ZNF596	1 interactors: STAT5A
Entrez ID		6776	7363
HPRD ID		03301	02507
Ensembl ID		ENSG00000126561	ENSG00000156096
Uniprot IDs		A8K6I5 K7EK35 P42229 Q59GY7	A6NCP7 G5E9X8 P06133
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Hormone Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus Protein Autophosphorylation Cellular Response To Stimulus Immune Response Signal Transduction Immune System Process Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Signaling Cell Communication Cellular Response To Cytokine Stimulus Regulation Of Immune Response Defense Response Response To Cytokine Positive Regulation Of Cellular Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-amino Acid Modification Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Peptide Response To Organonitrogen Compound Regulation Of Immune System Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Organ Development Response To Growth Factor Cytokine-mediated Signaling Pathway JAK-STAT Cascade Regulation Of MAPK Cascade Response To Peptide Hormone Neurotrophin TRK Receptor Signaling Pathway Response To Peptide Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Response To Growth Hormone Positive Regulation Of Metabolic Process Neurotrophin Signaling Pathway Anatomical Structure Development	Positive Regulation Of Mast Cell Differentiation Regulation Of Mast Cell Differentiation Development Of Secondary Male Sexual Characteristics Negative Regulation Of Mast Cell Apoptotic Process Creatinine Metabolic Process Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Mast Cell Proliferation Isoleucine Metabolic Process Allantoin Metabolic Process Taurine Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Erythrocyte Differentiation Prolactin Signaling Pathway Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Valine Metabolic Process Creatine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Succinate Metabolic Process Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Luteinization Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of B Cell Differentiation 2-oxoglutarate Metabolic Process Peyer's Patch Development Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Epithelial Cell Differentiation Involved In Prostate Gland Development Oxaloacetate Metabolic Process Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Differentiation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Activated T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Natural Killer Cell Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of B Cell Differentiation Positive Regulation Of Interleukin-2 Production Regulation Of Erythrocyte Differentiation Regulation Of Activated T Cell Proliferation T Cell Homeostasis Regulation Of Myeloid Cell Apoptotic Process Lipid Storage Prostate Gland Epithelium Morphogenesis Response To Growth Hormone
Tagcloud ?		advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely	accounting car cnv discover esr1 fdr genotyped glucuronidation glucuronosyltransferases livers pharmacogenetic pxr quantified tagsnps tfs udp ugt1a ugt1a1 ugt1a3 ugt1a4 ugt1a6 ugt1a9 ugts
Tagcloud (Difference) ?		advantaged apor arose b8 ba character coincides committed derive die dn epo epor erythropoietin f3epor homeotic hox hypothesize naturally normally preexisting shortened subclones switch truncated unexplored uniquely	accounting car cnv discover esr1 fdr genotyped glucuronidation glucuronosyltransferases livers pharmacogenetic pxr quantified tagsnps tfs udp ugt1a ugt1a1 ugt1a3 ugt1a4 ugt1a6 ugt1a9 ugts
Tagcloud (Intersection) ?