STAT5A and TEK

Number of citations: 0 (PubMedID 14726409)
Data Source: HPRD (in vivo)

		STAT5A	TEK
Name		signal transducer and activator of transcription 5A	TEK receptor tyrosine kinase
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Stress Fiber Extracellular Region Cytoplasm Centrosome Cytoskeleton Actin Filament Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Ciliary Basal Body Receptor Complex Membrane Raft Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Phosphate Ion Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activity Identical Protein Binding
	Biological Process	Mitotic Cell Cycle Luteinization Natural Killer Cell Differentiation Positive Regulation Of Endothelial Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Female Pregnancy Lactation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Lymphocyte Differentiation Regulation Of Cell Adhesion B Cell Differentiation Erythrocyte Differentiation Eosinophil Differentiation Regulation Of Epithelial Cell Differentiation Mammary Gland Development Positive Regulation Of Interleukin-2 Production Positive Regulation Of Natural Killer Cell Differentiation Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Reelin-mediated Signaling Pathway Interleukin-5-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Thrombopoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Population Proliferation Natural Killer Cell Mediated Cytotoxicity Gamma-delta T Cell Differentiation T Cell Homeostasis Response To Peptide Hormone Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Activated T Cell Proliferation Mast Cell Differentiation Positive Regulation Of Mast Cell Differentiation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Mammary Gland Epithelium Development Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Regulation Of Hemopoiesis Negative Regulation Of T-helper 17 Cell Lineage Commitment	Angiogenesis Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Hemopoiesis Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Establishment Or Maintenance Of Cell Polarity Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Positive Regulation Of MAPK Cascade Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Tie Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Glomerulus Vasculature Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Prolactin receptor signaling Nuclear signaling by ERBB4 Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Inactivation of CSF3 (G-CSF) signaling Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling Growth hormone receptor signaling	Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade
Drugs		None	Ampicillin Vandetanib N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Regorafenib Ponatinib Tivozanib Fostamatinib Ripretinib
Diseases		None	Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Asthma (childhood onset) ( 31036433 ) Crohn's disease ( 28067908 ) Heel bone mineral density ( 30598549 ) Inflammatory bowel disease ( 23128233 27569725 28067908 ) Low density lipoprotein cholesterol levels ( 32154731 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Adult asthma ( 27611488 ) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325 ) Asthma ( 27611488 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Cognitive decline (age-related) ( 28078323 ) Coronary artery disease ( 29212778 ) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821 )
Interacting Genes		72 interacting genes: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CPAP CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FBXW7 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK MAGEA12 MAPK1 MAPK3 MRPS6 NCOR2 NMI NR3C1 OLIG1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TET2 TSLP TXNDC11 UGT2B4 WASH2P ZNF596	26 interacting genes: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP CAV1 DOK2 DOK4 DUSP18 GRB14 GRB2 GRB7 IKBKG ILKAP PIK3R1 PTPN11 PTPRB PTPRR SHC1 SHC4 SOCS1 STAT5A STAT5B STYX TIE1 TNIP2
Entrez ID		6776	7010
HPRD ID		03301	02571
Ensembl ID		ENSG00000126561	ENSG00000120156
Uniprot IDs		A0A384N5W4 A0A7I2YQF1 A8K6I5 K7EK35 P42229 Q59GY7	Q02763 Q59HG2
PDB IDs		7TVA 7TVB 7UBT 7UC6 7UC7	1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V 4X3J 5MYA 5MYB 5UTK 6MWE 7E72
GO Terms Enriched among Interactors		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-7-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Immune System Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Receptor Signaling Pathway Via STAT Phosphorylation Phosphotyrosine Residue Binding Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Developmental Process Animal Organ Development Regulation Of ERK1 And ERK2 Cascade Protein Phosphorylation Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Developmental Process Response To Growth Factor Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Protein Kinase Activity Regulation Of Gene Expression Regulation Of Immune Response Identical Protein Binding Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Receptor Tyrosine Kinase Binding Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding Negative Regulation Of Developmental Process Neurotrophin TRKA Receptor Binding Positive Regulation Of Cell Activation ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Body Fluid Levels Positive Regulation Of Multicellular Organismal Process Regulation Of Innate Immune Response Angiogenesis Regulation Of MAPK Cascade Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Natural Killer Cell Mediated Immunity Phosphotyrosine Residue Binding Regulation Of Cell Migration Positive Regulation Of Immune System Process Regulation Of Cell Motility Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Insulin-like Growth Factor Receptor Binding Phosphoprotein Phosphatase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of ERK1 And ERK2 Cascade Protein Kinase Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Insulin Receptor Signaling Pathway Leukocyte Mediated Cytotoxicity Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signal Transduction Negative Regulation Of Cell Adhesion Response To Growth Factor Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Development Of Secondary Female Sexual Characteristics