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STAT5A and NR3C1
Number of citations of the paper that reports this interaction (PubMedID
9528750
)
53
Data Source:
HPRD
(in vitro, in vivo)
STAT5A
NR3C1
Description
signal transducer and activator of transcription 5A
nuclear receptor subfamily 3 group C member 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Centrosome
Spindle
Cytosol
Cytoskeleton
Membrane
Nuclear Speck
Protein-containing Complex
Synapse
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Phosphate Ion Binding
Sequence-specific DNA Binding
DNA-binding Transcription Factor Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Nuclear Receptor Activity
Nuclear Glucocorticoid Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Lipid Binding
TBP-class Protein Binding
Protein Kinase Binding
Estrogen Response Element Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Hsp90 Protein Binding
Steroid Hormone Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Mitotic Cell Cycle
Luteinization
Natural Killer Cell Differentiation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Lymphocyte Differentiation
Regulation Of Cell Adhesion
B Cell Differentiation
Erythrocyte Differentiation
Eosinophil Differentiation
Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Differentiation
Mast Cell Apoptotic Process
Negative Regulation Of Mast Cell Apoptotic Process
Myeloid Cell Apoptotic Process
Negative Regulation Of Myeloid Cell Apoptotic Process
T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Reelin-mediated Signaling Pathway
Interleukin-5-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Thrombopoietin-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Natural Killer Cell Mediated Cytotoxicity
Gamma-delta T Cell Differentiation
T Cell Homeostasis
Response To Peptide Hormone
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Activated T Cell Proliferation
Mast Cell Differentiation
Positive Regulation Of Mast Cell Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Prostate Gland Epithelium Morphogenesis
Epithelial Cell Differentiation Involved In Prostate Gland Development
Mammary Gland Epithelium Development
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Regulation Of Hemopoiesis
Negative Regulation Of T-helper 17 Cell Lineage Commitment
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gluconeogenesis
Chromatin Organization
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Chromosome Segregation
Signal Transduction
Glucocorticoid Metabolic Process
Response To Wounding
Gene Expression
Microglia Differentiation
Adrenal Gland Development
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Regulation Of Glucocorticoid Biosynthetic Process
Nuclear Receptor-mediated Corticosteroid Signaling Pathway
Synaptic Transmission, Glutamatergic
Maternal Behavior
Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Astrocyte Differentiation
Cell Division
Response To Glucocorticoid
Response To Cortisol
Mammary Gland Duct Morphogenesis
Motor Behavior
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Dexamethasone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Neuroinflammatory Response
Response To Ketone
Positive Regulation Of MiRNA Transcription
Pathways
Prolactin receptor signaling
Nuclear signaling by ERBB4
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Inactivation of CSF3 (G-CSF) signaling
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Growth hormone receptor signaling
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
SUMOylation of intracellular receptors
PTK6 Expression
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Regulation of NPAS4 gene transcription
Drugs
Flunisolide
Diflorasone
Alclometasone
Medrysone
Amcinonide
Fluorometholone
Megestrol acetate
Levonorgestrel
Beclomethasone dipropionate
Progesterone
Spironolactone
Betamethasone
Desoximetasone
Fluticasone propionate
Fluocinolone acetonide
Ulobetasol
Triamcinolone
Prednisone
Flumethasone
Fludrocortisone
Norethisterone
Hydrocortisone
Mometasone
Hydrocortamate
Mifepristone
Clocortolone
Flurandrenolide
Prednisolone
Loteprednol etabonate
Rimexolone
Methylprednisolone
Clobetasol propionate
Fluocinonide
Prednicarbate
Fluoxymesterone
Budesonide
Dexamethasone
Desonide
Cortisone acetate
Paramethasone
Drospirenone
Ciclesonide
Hexane-1,6-Diol
Aldosterone
ORG-34517
Difluprednate
Ulipristal
Fluticasone furoate
Tixocortol
Difluocortolone
Gestrinone
Deflazacort
Onapristone
Cortivazol
Clobetasone
Fluticasone
Mometasone furoate
Hydrocortisone aceponate
Hydrocortisone acetate
Hydrocortisone butyrate
Hydrocortisone cypionate
Hydrocortisone phosphate
Hydrocortisone probutate
Hydrocortisone valerate
Segesterone acetate
Prednisolone phosphate
Dexamethasone acetate
Betamethasone phosphate
Prednisolone acetate
Diseases
46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
23128233
27569725
28067908
)
Low density lipoprotein cholesterol levels (
32154731
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Appendicular lean mass (
33097823
)
Atrial fibrillation (
29892015
30061737
)
Hip circumference adjusted for BMI (
34021172
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Night sleep phenotypes (
27126917
)
PR interval (
32439900
)
Spatial processing (
31596458
)
Interacting Genes
72 interacting genes:
AQP11
BMX
BRCA1
BRCA2
BTK
CBL
CCR5
CD247
CEBPB
CPAP
CRK
CRKL
CSNK2B
CTLA4
CYP2C9
EGFR
EP300
EPAS1
EPOR
ERBB4
ESR1
ESR2
FBXW7
FN1
GHR
GLUD1
GNB2
HELZ
IL2RB
IL2RG
IL7R
INSR
JAK1
JAK2
JAK3
KIT
LCK
MAGEA12
MAPK1
MAPK3
MRPS6
NCOR2
NMI
NR3C1
OLIG1
PDGFRA
PDGFRB
POM121C
POU2F1
PPIB
PPP2CA
PRMT1
PRTFDC1
PTPN1
PTPN11
PTPN2
RBMX
SHC1
SRC
STAP2
STAT1
STAT3
STAT5B
SYK
TCF12
TEK
TET2
TSLP
TXNDC11
UGT2B4
WASH2P
ZNF596
167 interacting genes:
ABCC1
ADA
AR
ARPC5
BAG1
C1orf94
CALM1
CALR
CEBPA
CEBPB
CENPB
CHD9
COPS6
CREB1
CREBBP
DAP3
DAPK1
DCAF6
DDX54
DNMT3L
DOCK3
DTD1
ECD
EFHC2
EGFR
EP300
EPB41L1
ETS1
ETS2
FAM161B
FKBP4
FTH1
FYN
GNB1
GNB2
GRIP1
H3C1
HDAC1
HDAC6
HMGB1
HMGB2
HMOX2
HNRNPA1
HNRNPU
HSP90AA1
HSP90AB1
HSPA1A
HSPD1
IDE
IFNGR2
JMJD1C
JUN
KAT5
KDM5A
KPNA2
KRTCAP3
LCK
LCOR
LPXN
LRIF1
MAFF
MAPK1
MAPK15
MAPK8
MDM2
MED1
MED14
MED25
MSX2
NCL
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NEDD4L
NFKB1
NFKB2
NR0B1
NR0B2
NR1H3
NR2E3
NR2F2
NR2F6
NR3C2
NR4A1
NRIP1
NUP54
ONECUT1
OSGEP
PBX1
PELP1
PIAS2
POLR1D
POU1F1
POU2F1
POU2F2
PPARGC1A
PRDX3
PRKACA
PRKDC
PRPF6
PSMC3IP
PTGES3
PTMS
RACK1
RAD54L2
RAD9A
RAF1
RAN
RARA
RBM14
RELA
RFPL2
RNF14
RXRB
SFN
SGTA
SHKBP1
SLC25A4
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SMARCD1
SMARCE1
SPIN2A
SRA1
SRC
STAT3
STAT5A
STAT5B
STRN3
STUB1
SUMO1
SUMO4
SVIL
SYT1
TADA2A
TBP
TDG
TGFB1I1
TMF1
TNS4
TP53
TRIM24
TRIM28
TSG101
TXN
UBB
UBE2I
UBE2L3
UBE3A
UBR1
UBR5
UHRF1
USP2
WTIP
YWHAH
ZBTB16
ZBTB20
ZBTB3
ZBTB9
ZNF496
Entrez ID
6776
2908
HPRD ID
03301
00679
Ensembl ID
ENSG00000126561
ENSG00000113580
Uniprot IDs
A0A384N5W4
A0A7I2YQF1
A8K6I5
K7EK35
P42229
Q59GY7
E5KQF5
E5KQF6
F1D8N4
P04150
PDB IDs
7TVA
7TVB
7UBT
7UC6
7UC7
1M2Z
1NHZ
1P93
3BQD
3CLD
3E7C
3H52
3K22
3K23
4CSJ
4HN5
4HN6
4LSJ
4MDD
4P6W
4P6X
4UDC
4UDD
5CBX
5CBY
5CBZ
5CC1
5E69
5E6A
5E6B
5E6C
5E6D
5EMC
5EMP
5EMQ
5G3J
5G5W
5NFP
5NFT
5UC1
5UC3
5VA0
5VA7
6BQU
6CFN
6DXK
6EL6
6EL7
6EL9
6X6D
6X6E
6YMO
6YO8
6YOS
7KRJ
7KW7
7PRV
7PRW
7PRX
8A9G
8FFV
8FFW
8VKZ
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cytokine-mediated Signaling Pathway
Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Cell Surface Receptor Signaling Pathway Via STAT
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-7-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune System Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Phosphorylation
Phosphotyrosine Residue Binding
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Developmental Process
Animal Organ Development
Regulation Of ERK1 And ERK2 Cascade
Protein Phosphorylation
Regulation Of Multicellular Organismal Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Developmental Process
Response To Growth Factor
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Activity
Regulation Of Gene Expression
Regulation Of Immune Response
Identical Protein Binding
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Positive Regulation Of Biosynthetic Process
Nucleoplasm
Nucleus
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Chromatin
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Transcription Coactivator Activity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Intracellular Receptor Signaling Pathway
Response To Lipid
Negative Regulation Of Biosynthetic Process
Chromatin Binding
Response To Hormone
Nuclear Receptor-mediated Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nuclear Receptor Binding
Nuclear Glucocorticoid Receptor Binding
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Protein-containing Complex
Hormone-mediated Signaling Pathway
Transcription Regulator Complex
Enzyme Binding
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Cellular Response To Hormone Stimulus
Tagcloud
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Tagcloud (Intersection)
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