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STAT5A and PDGFRA
Number of citations of the paper that reports this interaction (PubMedID
9484840
)
0
Data Source:
HPRD
(in vitro)
STAT5A
PDGFRA
Description
signal transducer and activator of transcription 5A
platelet derived growth factor receptor alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Microvillus
Cilium
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Cell Junction
Protein-containing Complex
Cell Projection
Receptor Complex
Platelet-derived Growth Factor Receptor-ligand Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Phosphate Ion Binding
Sequence-specific DNA Binding
DNA-binding Transcription Factor Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet-derived Growth Factor Alpha-receptor Activity
Vascular Endothelial Growth Factor Receptor Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Vascular Endothelial Growth Factor Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Biological Process
Mitotic Cell Cycle
Luteinization
Natural Killer Cell Differentiation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Lymphocyte Differentiation
Regulation Of Cell Adhesion
B Cell Differentiation
Erythrocyte Differentiation
Eosinophil Differentiation
Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Differentiation
Mast Cell Apoptotic Process
Negative Regulation Of Mast Cell Apoptotic Process
Myeloid Cell Apoptotic Process
Negative Regulation Of Myeloid Cell Apoptotic Process
T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-4-mediated Signaling Pathway
Reelin-mediated Signaling Pathway
Interleukin-5-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Thrombopoietin-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Natural Killer Cell Mediated Cytotoxicity
Gamma-delta T Cell Differentiation
T Cell Homeostasis
Response To Peptide Hormone
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Activated T Cell Proliferation
Mast Cell Differentiation
Positive Regulation Of Mast Cell Differentiation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Prostate Gland Epithelium Morphogenesis
Epithelial Cell Differentiation Involved In Prostate Gland Development
Mammary Gland Epithelium Development
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Regulation Of Hemopoiesis
Negative Regulation Of T-helper 17 Cell Lineage Commitment
Luteinization
In Utero Embryonic Development
Cell Activation
Hematopoietic Progenitor Cell Differentiation
Chemotaxis
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Estrogen Metabolic Process
Positive Regulation Of Cell Population Proliferation
Female Gonad Development
Anatomical Structure Morphogenesis
Animal Organ Morphogenesis
Negative Regulation Of Platelet Activation
Cell Migration
Peptidyl-tyrosine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Extracellular Matrix Organization
Lung Development
Adrenal Gland Development
Positive Regulation Of Cell Migration
Male Genitalia Development
Regulation Of Actin Cytoskeleton Organization
Leydig Cell Differentiation
Cellular Response To Reactive Oxygen Species
Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Odontogenesis Of Dentin-containing Tooth
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Embryonic Digestive Tract Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Embryonic Skeletal System Morphogenesis
Skeletal System Morphogenesis
Positive Regulation Of Calcium-mediated Signaling
White Fat Cell Differentiation
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Roof Of Mouth Development
Face Morphogenesis
Cell Chemotaxis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Amino Acid Stimulus
Metanephric Glomerular Capillary Formation
Regulation Of Mesenchymal Stem Cell Differentiation
Pathways
Prolactin receptor signaling
Nuclear signaling by ERBB4
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Inactivation of CSF3 (G-CSF) signaling
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Growth hormone receptor signaling
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Imatinib-resistant PDGFR mutants
Sunitinib-resistant PDGFR mutants
Regorafenib-resistant PDGFR mutants
Sorafenib-resistant PDGFR mutants
PDGFR mutants bind TKIs
Drugs
Becaplermin
Imatinib
Sunitinib
XL820
Olaratumab
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foreskin keratinocyte (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Ripretinib
Diseases
Glioma
GWAS
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
23128233
27569725
28067908
)
Low density lipoprotein cholesterol levels (
32154731
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Adult asthma (
27611488
)
Asthma (
27611488
)
Blood protein levels (
30072576
)
Cadmium levels (
26025379
)
Core binding factor acute myeloid leukemia (
27903959
)
Corneal astigmatism (
29422769
22144915
)
Corneal curvature (
24963161
23401653
21665993
)
Height (
18193045
)
Hematocrit (
29403010
)
Hemoglobin (
29403010
)
Lupus nephritis in systemic lupus erythematosus (
24925725
)
Macular thickness (
30535121
)
Mean corpuscular hemoglobin (
20139978
29403010
)
Mean corpuscular volume (
29403010
20139978
)
Platelet count (
29403010
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Pulse pressure (
30578418
)
Red blood cell count (
28453575
29403010
20139978
)
Serum VEGFR2 concentration (
25411163
)
Systolic blood pressure (
30578418
)
Uterine fibroids (
30194396
31649266
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
72 interacting genes:
AQP11
BMX
BRCA1
BRCA2
BTK
CBL
CCR5
CD247
CEBPB
CPAP
CRK
CRKL
CSNK2B
CTLA4
CYP2C9
EGFR
EP300
EPAS1
EPOR
ERBB4
ESR1
ESR2
FBXW7
FN1
GHR
GLUD1
GNB2
HELZ
IL2RB
IL2RG
IL7R
INSR
JAK1
JAK2
JAK3
KIT
LCK
MAGEA12
MAPK1
MAPK3
MRPS6
NCOR2
NMI
NR3C1
OLIG1
PDGFRA
PDGFRB
POM121C
POU2F1
PPIB
PPP2CA
PRMT1
PRTFDC1
PTPN1
PTPN11
PTPN2
RBMX
SHC1
SRC
STAP2
STAT1
STAT3
STAT5B
SYK
TCF12
TEK
TET2
TSLP
TXNDC11
UGT2B4
WASH2P
ZNF596
62 interacting genes:
AKT1
ARNT
AURKA
BECN1
CAV1
CAV3
CBL
CCND2
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CRK
CRKL
EGFR
ERBB2
ERBB3
FBXO25
FZR1
GRB14
GRM1
HGF
ITGAV
ITGB3
JAK1
KASH5
KDELR2
LATS2
MAP2K5
MYC
NF2
NHERF1
PDGFA
PDGFB
PDGFC
PDGFRB
PIK3CA
PIK3R1
PLCG1
PLPP6
PRMT5
PTPN11
RAF1
SHB
SHF
SMURF1
SNX2
SNX4
SNX6
SRPK1
STAT1
STAT3
STAT5A
STAT5B
STK11
TERT
TGFBR2
TP53
TTYH2
ULBP2
Entrez ID
6776
5156
HPRD ID
03301
01429
Ensembl ID
ENSG00000126561
ENSG00000134853
Uniprot IDs
A0A384N5W4
A0A7I2YQF1
A8K6I5
K7EK35
P42229
Q59GY7
P16234
PDB IDs
7TVA
7TVB
7UBT
7UC6
7UC7
1GQ5
5GRN
5K5X
6A32
6JOI
6JOJ
6JOK
6JOL
7LBF
7RAM
8PQH
8PQI
8PQJ
8PQK
9GZH
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Cytokine-mediated Signaling Pathway
Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of MAPK Cascade
Positive Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Cell Surface Receptor Signaling Pathway Via STAT
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-7-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Immune System Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Phosphorylation
Phosphotyrosine Residue Binding
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Developmental Process
Animal Organ Development
Regulation Of ERK1 And ERK2 Cascade
Protein Phosphorylation
Regulation Of Multicellular Organismal Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Developmental Process
Response To Growth Factor
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Growth Hormone Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Activity
Regulation Of Gene Expression
Regulation Of Immune Response
Identical Protein Binding
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Population Proliferation
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signal Transduction
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Developmental Process
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Regulation Of Epithelial Cell Proliferation
Developmental Process
Cellular Developmental Process
Regulation Of Mitotic Cell Cycle
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Cycle
Regulation Of Apoptotic Process
Cell Population Proliferation
Regulation Of Programmed Cell Death
Regulation Of MAPK Cascade
Regulation Of Cellular Component Organization
Negative Regulation Of Apoptotic Process
Regulation Of Cell Differentiation
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Adhesion
Cell Differentiation
Animal Organ Development
Negative Regulation Of Cell Differentiation
Regulation Of Fibroblast Proliferation
Positive Regulation Of Cell Migration
Intracellular Signal Transduction
Intracellular Signaling Cassette
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Growth
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Cell Motility
Regulation Of Cell Development
Response To Epidermal Growth Factor
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Developmental Process
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