ANKS1B and LRP2

Number of citations of the paper that reports this interaction (PMID 12508107)
4

Data Source:
HPRD (two hybrid)

		ANKS1B	LRP2
Gene Name		ankyrin repeat and sterile alpha motif domain containing 1B	low density lipoprotein receptor-related protein 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Postsynaptic Density Cajal Body Cell Junction Dendritic Spine Postsynaptic Membrane	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Ephrin Receptor Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process		Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs			Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 20966902) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Response to antipsychotic treatment ( 19721433) Waist circumference ( 20966902) Working memory ( 21107309)	Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		8 interactors: APP EGFR ERBB2 ERBB4 HTR2A LRP1 LRP2 UBC	48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		56899	4036
HPRD ID		07426	02509
Ensembl ID		ENSG00000185046	ENSG00000081479
Uniprot IDs		B1VKB5 B7Z9I9 Q6V0K8 Q7Z6G8	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		2EAM 2KE7 2KIV 2M38	2M0P
Enriched GO Terms of Interacting Partners?		Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Positive Regulation Of Transferase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorylation Regulation Of Catalytic Activity Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Proliferation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of MAP Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of ERBB Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Diterpenoid Metabolic Process Regulation Of Phospholipase Activity Response To Light Stimulus Positive Regulation Of Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Response To External Stimulus Cell Surface Receptor Signaling Pathway Central Nervous System Development Regulation Of Phospholipase A2 Activity	Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation
Tagcloud ?			adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?			adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Intersection) ?