ANKS1B and RIN1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid, two hybrid)

		ANKS1B	RIN1
Description		ankyrin repeat and sterile alpha motif domain containing 1B	Ras and Rab interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cajal Body Cell Projection Dendritic Spine Synapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	Protein Binding Ephrin Receptor Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Ephrin Receptor Signaling Pathway	Endocytosis Signal Transduction Vesicle-mediated Transport Intracellular Signal Transduction
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat percentage ( 31752434) Body mass index ( 20966902) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Body size at age 10 ( 32376654) Electrodermal activity ( 25387706) Hip circumference adjusted for BMI ( 34021172) Left-handedness ( 32989287) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Response to antipsychotic treatment ( 19721433) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Waist circumference ( 20966902)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		14 interacting genes: APP CASS4 CREBBP EGFR ERBB2 ERBB4 HSF2BP HTR2A LRP1 LRP2 NCK2 RHOA RIN1 UBC	49 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP ITSN1 KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1
Entrez ID		56899	9610
HPRD ID		07426	05813
Ensembl ID		ENSG00000185046	ENSG00000174791
Uniprot IDs		A0A804HKX1 B1VKB5 B7Z9I9 F8VR14 Q6V0K8 Q7Z6G8	A0A0S2Z4T5 A0A0S2Z4U0 Q13671
PDB IDs		2EAM 2KE7 2KIV 2M38
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Metabolic Process Receptor Complex Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation ERBB2 Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Epidermal Growth Factor Receptor Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Signal Transduction Positive Regulation Of Metabolic Process Response To Growth Factor Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Astrocyte Activation Involved In Immune Response Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Programmed Cell Death ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Lysosomal Protein Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cell Population Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Phosphorylation ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Localization Basal Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade ERBB4 Signaling Pathway Endocytic Vesicle Clathrin-coated Pit	Cytosol Cytoplasm Perinuclear Region Of Cytoplasm Phosphoserine Residue Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade ERBB Signaling Pathway GDP Binding Intracellular Signaling Cassette MAPK Cascade Identical Protein Binding Regulation Of Intracellular Signal Transduction Protein Sequestering Activity ERBB3:ERBB2 Complex Regulation Of Autophagy Melanosome Positive Regulation Of Intracellular Signal Transduction Cellular Localization Vesicle-mediated Transport Schwann Cell Development Protein Tyrosine Kinase Activity Glial Cell Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Protein Localization Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Establishment Of Localization In Cell Regulation Of Cell Communication Signal Transduction Regulation Of Signaling ErbB-3 Class Receptor Binding Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Actin Filament-based Process Protein Binding Regulation Of Establishment Of T Cell Polarity Regulation Of Signal Transduction Protein Modification Process Regulation Of Fibroblast Proliferation Regulation Of ERK1 And ERK2 Cascade Protein Phosphatase Binding Myelination Axon Ensheathment Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERBB2-EGFR Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?