ANKS1B

Gene Name		ankyrin repeat and sterile alpha motif domain containing 1B
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Gene Ontology Annotations	Cellular Component	Cytoplasm Postsynaptic Density Cajal Body Cell Junction Dendritic Spine Postsynaptic Membrane
	Molecular Function	Ephrin Receptor Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 20966902) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) Response to antipsychotic treatment ( 19721433) Waist circumference ( 20966902) Working memory ( 21107309)
Protein-protein Interactions		8 interactors: APP EGFR ERBB2 ERBB4 HTR2A LRP1 LRP2 UBC
Entrez ID		56899
HPRD ID		07426
Ensembl ID		ENSG00000185046
Uniprot IDs		B1VKB5 B7Z9I9 Q6V0K8 Q7Z6G8
PDB IDs		2EAM 2KE7 2KIV 2M38
Enriched GO Terms of Interacting Partners?		Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Positive Regulation Of Transferase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorylation Regulation Of Catalytic Activity Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Proliferation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of MAP Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of ERBB Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cellular Biosynthetic Process Diterpenoid Metabolic Process Regulation Of Phospholipase Activity Response To Light Stimulus Positive Regulation Of Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Response To External Stimulus Cell Surface Receptor Signaling Pathway Central Nervous System Development Regulation Of Phospholipase A2 Activity
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