CERS1 and BDKRB1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CERS1	BDKRB1
Description		ceramide synthase 1	bradykinin receptor B1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	N-acyltransferase Activity Transferase Activity Sphingosine N-acyltransferase Activity	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Lipid Metabolic Process Sphingolipid Metabolic Process Brain Development Negative Regulation Of Cardiac Muscle Hypertrophy Sphingolipid Biosynthetic Process Cellular Response To Mycotoxin Negative Regulation Of D-glucose Import Ceramide Biosynthetic Process Cellular Response To Xenobiotic Stimulus Cellular Response To UV-A Cellular Response To Dithiothreitol Positive Regulation Of Mitophagy	Positive Regulation Of Leukocyte Migration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Mechanical Stimulus Cell Migration Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Sphingolipid de novo biosynthesis	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: BDKRB1 DRD2 HTR4 LTB4R2 MAPK6	32 interacting genes: CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C LTAP1 MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22
Entrez ID		10715	623
HPRD ID		12114	02639
Ensembl ID		ENSG00000223802	ENSG00000100739
Uniprot IDs		B4DE47 P27544 Q5XG75	P46663
PDB IDs			7EIB
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Cell Migration Signal Transduction Regulation Of Blood Pressure Regulation Of Sequestering Of Calcium Ion Cell Motility Bradykinin Receptor Activity Negative Regulation Of Synaptic Transmission, Glutamatergic Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Histamine Regulation Of Synapse Structural Plasticity Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Regulation Of Synapse Organization Cerebral Cortex GABAergic Interneuron Migration Chemical Synaptic Transmission Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Catecholamine Uptake Dopamine Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Adenohypophysis Development Negative Regulation Of Dephosphorylation Response To Inactivity Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Migration Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Peristalsis Regulation Of Body Fluid Levels Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Regulation Of Locomotion Involved In Locomotory Behavior Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Urine Volume	Endoplasmic Reticulum Membrane Membrane Ferrous Iron Transmembrane Transporter Activity Brain Development Iron Ion Transmembrane Transporter Activity Negative Regulation Of Transport Profilin Binding
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