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NDNL2 and NGFR
Number of citations of the paper that reports this interaction (PMID
14593116
)
23
Data Source:
BioGRID
(affinity chromatography technology, two hybrid, pull down)
NDNL2
NGFR
Gene Name
necdin-like 2
nerve growth factor receptor
Image
Gene Ontology Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Cytoplasm
Smc5-Smc6 Complex
Extracellular Region
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Neuronal Postsynaptic Density
Molecular Function
Protein Binding
Signal Transducer Activity
Receptor Activity
Transmembrane Signaling Receptor Activity
Death Receptor Activity
Protein Binding
Rab GTPase Binding
Ubiquitin Protein Ligase Binding
Nerve Growth Factor Binding
Biological Process
DNA Repair
DNA Recombination
Positive Regulation Of Protein Ubiquitination
Regulation Of Growth
Intracellular Protein Transport
Axon Guidance
Central Nervous System Development
Detection Of Temperature Stimulus
Nerve Development
Hair Follicle Morphogenesis
Membrane Protein Intracellular Domain Proteolysis
Circadian Regulation Of Gene Expression
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cell Cycle
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Regulation Of Axonogenesis
Negative Regulation Of Axonogenesis
Positive Regulation Of Axonogenesis
Negative Regulation Of Hair Follicle Development
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways
Regulated proteolysis of p75NTR
Signalling by NGF
NF-kB is activated and signals survival
p75NTR recruits signalling complexes
p75NTR regulates axonogenesis
p75NTR negatively regulates cell cycle via SC1
Cell death signalling via NRAGE, NRIF and NADE
Axonal growth stimulation
Ceramide signalling
p75 NTR receptor-mediated signalling
Axonal growth inhibition (RHOA activation)
NRIF signals cell death from the nucleus
NRAGE signals death through JNK
p75NTR signals via NF-kB
NFG and proNGF binds to p75NTR
NADE modulates death signalling
Drugs
Diseases
GWAS
Immune reponse to smallpox (secreted IL-2) (
22610502
)
Prostate cancer (
23535732
)
Protein-Protein Interactions
5 interactors:
E2F1
EID3
NGFR
PJA1
TRIM28
45 interactors:
ANXA7
BEX1
CAV1
CD80
CDKN1A
FSCN1
GRB2
H2AFX
IL2
KIDINS220
LINGO1
MAG
MAGED1
MAGEH1
MAPK1
MAPK3
NDN
NDNL2
NFKBIB
NGF
NGFRAP1
NTF4
NTRK1
NTRK2
NTRK3
PRKACB
PTPN13
RCC1
RIPK2
RPN2
RTN4R
SHC1
SMN1
SORT1
STMN2
TK1
TRA2B
TRADD
TRAF2
TRAF4
TRAF6
TRIM37
TTR
UFD1L
ZNF274
Entrez ID
56160
4804
HPRD ID
10503
01197
Ensembl ID
ENSG00000185115
ENSG00000064300
Uniprot IDs
Q96MG7
P08138
PDB IDs
3NW0
3EWV
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Fibroblast Proliferation
Regulation Of Fibroblast Proliferation
Negative Regulation Of DNA Demethylation
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Hair Follicle Development
Positive Regulation Of Apoptotic Signaling Pathway
Lens Fiber Cell Apoptotic Process
Negative Regulation Of Hair Cycle
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Convergent Extension Involved In Axis Elongation
Positive Regulation Of Intracellular Transport
Organ Development
Regulation Of Genetic Imprinting
DNA Methylation Involved In Embryo Development
Anoikis
Apoptotic Signaling Pathway
Positive Regulation Of Odontogenesis
Cellular Response To Stress
Convergent Extension
Negative Regulation Of Viral Release From Host Cell
Regulation Of Intracellular Transport
Regulation Of Odontogenesis Of Dentin-containing Tooth
Membrane Protein Intracellular Domain Proteolysis
Regulation Of Hair Follicle Development
System Development
Regulation Of Glucose Import In Response To Insulin Stimulus
Morphogenesis Of An Epithelium
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Hair Cycle
Regulation Of Viral Release From Host Cell
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Protein Sumoylation
MRNA Stabilization
Embryonic Placenta Morphogenesis
Protein Ubiquitination
Positive Regulation Of Apoptotic Process
Detection Of Temperature Stimulus
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Programmed Cell Death
DNA Repair
Regulation Of Odontogenesis
Protein Modification By Small Protein Conjugation
Positive Regulation Of Cell Death
Multicellular Organismal Development
Tissue Morphogenesis
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Axis Elongation
Hair Follicle Morphogenesis
Neurotrophin Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Response To Organic Substance
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Phosphorylation
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of MAPK Cascade
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Kinase Activity
Positive Regulation Of Signal Transduction
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Metabolic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Apoptotic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Catalytic Activity
Signal Transduction
Cellular Response To Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Neuron Projection Development
TRIF-dependent Toll-like Receptor Signaling Pathway
Response To Stimulus
Developmental Process
Regulation Of MAP Kinase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud
?
acidophilia
astrocyte
axotomized
chat
choline
cholinergic
cresyl
depressed
die
elicit
fate
ff
fimbria
fornix
immunoreactive
itfs
jun
jund
krox
lose
medial
microglial
mystery
parvalbumin
septal
septohippocampal
transection
transferase
violet
Tagcloud (Difference)
?
acidophilia
astrocyte
axotomized
chat
choline
cholinergic
cresyl
depressed
die
elicit
fate
ff
fimbria
fornix
immunoreactive
itfs
jun
jund
krox
lose
medial
microglial
mystery
parvalbumin
septal
septohippocampal
transection
transferase
violet
Tagcloud (Intersection)
?