NSMCE3 and NGFR

Number of citations of the paper that reports this interaction (PubMedID 14593116)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down)

		NSMCE3	NGFR
Description		NSE3 component of SMC5/6 complex	nerve growth factor receptor
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Smc5-Smc6 Complex	Extracellular Region Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Membrane Growth Cone Neuromuscular Junction Cell Projection Dendritic Spine Perikaryon Organelle Synapse Presynapse
	Molecular Function	Protein Binding Protein Dimerization Activity	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Sumoylation Positive Regulation Of Protein Ubiquitination Regulation Of Telomere Maintenance Cellular Response To UV Regulation Of Macromolecule Metabolic Process Cellular Response To Radiation Cellular Response To Hydroxyurea Regulation Of Primary Metabolic Process Chromatin Looping	Intracellular Glucose Homeostasis Hair Follicle Development Intracellular Protein Transport Apoptotic Process Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Central Nervous System Development Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Detection Of Temperature Stimulus Nerve Development Cell Differentiation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Skin Development Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Rhythmic Process Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of MiRNA Transcription Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		SUMOylation of DNA damage response and repair proteins	Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		3 interacting genes: E2F1 NGFR TRIM28	50 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274
Entrez ID		56160	4804
HPRD ID		10503	01197
Ensembl ID		ENSG00000185115	ENSG00000064300
Uniprot IDs		Q96MG7	P08138
PDB IDs		5HVQ 5WY5	2N80 2N83 2N97 3EWV 5ZGG 7CSQ 8X8T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Positive Regulation Of Protein Localization To Nucleus RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Protein Localization To Nucleus Dorsal Aorta Development Krueppel-associated Box Domain Binding Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Fat Cell Proliferation Positive Regulation Of DNA-templated Transcription Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Rb-E2F Complex Negative Regulation Of Hair Follicle Development Death Receptor Activity Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding Neurotrophin Binding Convergent Extension Involved In Axis Elongation Ubiquitin-like Protein Ligase Activity Embryonic Placenta Morphogenesis Chromo Shadow Domain Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Odontogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Protein Localization Anoikis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA Binding Positive Regulation Of Apoptotic Process Regulation Of Odontogenesis Suppression Of Viral Release By Host Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Hair Follicle Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway SUMO Transferase Activity Genomic Imprinting Positive Regulation Of Glial Cell Proliferation Detection Of Temperature Stimulus Positive Regulation Of Endothelial Cell Apoptotic Process DNA-binding Transcription Activator Activity Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Hair Cycle	Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Response To Growth Factor Signal Transduction Response To Nerve Growth Factor Regulation Of Protein Metabolic Process Protein-containing Complex Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Enzyme Binding Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Identical Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Signaling Adaptor Activity Regulation Of Gene Expression Regulation Of Cellular Component Organization Circadian Rhythm Regulation Of Macromolecule Biosynthetic Process Caveolin-mediated Endocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Myelination Apoptotic Signaling Pathway Axon Ensheathment Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Radiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?