NSMCE3 and TRIM28

Number of citations of the paper that reports this interaction (PubMedID 20864041)
42

Data Source:
BioGRID (pull down)

		NSMCE3	TRIM28
Description		NSE3 component of SMC5/6 complex	tripartite motif containing 28
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Smc5-Smc6 Complex	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Protein Dimerization Activity	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Sumoylation Positive Regulation Of Protein Ubiquitination Regulation Of Telomere Maintenance Cellular Response To UV Regulation Of Macromolecule Metabolic Process Cellular Response To Radiation Cellular Response To Hydroxyurea Regulation Of Primary Metabolic Process Chromatin Looping	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Embryo Implantation Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus Epigenetic Programming Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Genomic Imprinting
Pathways		SUMOylation of DNA damage response and repair proteins	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		3 interacting genes: E2F1 NGFR TRIM28	90 interacting genes: CBX1 CBX3 CBX5 CCAR2 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 EAF1 ESR1 FBP1 FES H4C1 HDAC10 HTRA2 IRF1 IRF7 LIN28A LINC00624 LYN MAGEA2 MAGEA2B MAGEA6 MAGEC2 MAGED1 MAPKAPK2 MCM3 MCM5 MORC2 MYB NR3C1 NR4A1 NR4A3 NSMCE3 OGT PFDN5 PHF13 PPP2CA PRKAA1 PTEN RB1 RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SMURF2 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2L6 UBE2N UBE2U UBE3D URI1 VHL VIM YWHAQ ZBTB33 ZNF10 ZNF133 ZNF197 ZNF274 ZNF354A ZNF354C ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93
Entrez ID		56160	10155
HPRD ID		10503	03445
Ensembl ID		ENSG00000185115	ENSG00000130726
Uniprot IDs		Q96MG7	Q13263
PDB IDs		5HVQ 5WY5	1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1 7Z36
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Positive Regulation Of Protein Localization To Nucleus RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Protein Localization To Nucleus Dorsal Aorta Development Krueppel-associated Box Domain Binding Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Fat Cell Proliferation Positive Regulation Of DNA-templated Transcription Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Rb-E2F Complex Negative Regulation Of Hair Follicle Development Death Receptor Activity Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding Neurotrophin Binding Convergent Extension Involved In Axis Elongation Ubiquitin-like Protein Ligase Activity Embryonic Placenta Morphogenesis Chromo Shadow Domain Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Odontogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Protein Localization Anoikis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA Binding Positive Regulation Of Apoptotic Process Regulation Of Odontogenesis Suppression Of Viral Release By Host Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Hair Follicle Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway SUMO Transferase Activity Genomic Imprinting Positive Regulation Of Glial Cell Proliferation Detection Of Temperature Stimulus Positive Regulation Of Endothelial Cell Apoptotic Process DNA-binding Transcription Activator Activity Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Hair Cycle	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Ubiquitin Conjugating Enzyme Activity Nucleoplasm Cellular Response To Stress DNA Damage Response Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex PML Body DNA Binding Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Binding Protein Catabolic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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