NSMCE3

Description		NSE3 component of SMC5/6 complex
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Smc5-Smc6 Complex
	Molecular Function	Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Sumoylation Positive Regulation Of Protein Ubiquitination Regulation Of Telomere Maintenance Cellular Response To UV Regulation Of Macromolecule Metabolic Process Cellular Response To Radiation Cellular Response To Hydroxyurea Regulation Of Primary Metabolic Process Chromatin Looping
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: E2F1 NGFR TRIM28
Entrez ID		56160
HPRD ID		10503
Ensembl ID		ENSG00000185115
Uniprot IDs		Q96MG7
PDB IDs		5HVQ 5WY5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Positive Regulation Of Protein Localization To Nucleus RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Protein Localization To Nucleus Dorsal Aorta Development Krueppel-associated Box Domain Binding Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Fat Cell Proliferation Positive Regulation Of DNA-templated Transcription Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Rb-E2F Complex Negative Regulation Of Hair Follicle Development Death Receptor Activity Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding Neurotrophin Binding Convergent Extension Involved In Axis Elongation Ubiquitin-like Protein Ligase Activity Embryonic Placenta Morphogenesis Chromo Shadow Domain Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Odontogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Protein Localization Anoikis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA Binding Positive Regulation Of Apoptotic Process Regulation Of Odontogenesis Suppression Of Viral Release By Host Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Hair Follicle Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway SUMO Transferase Activity Genomic Imprinting Positive Regulation Of Glial Cell Proliferation Detection Of Temperature Stimulus Positive Regulation Of Endothelial Cell Apoptotic Process DNA-binding Transcription Activator Activity Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Hair Cycle
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