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HSF1 and FKBP4
Number of citations of the paper that reports this interaction (PubMedID
9222609
)
0
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HSF1
FKBP4
Description
heat shock transcription factor 1
FKBP prolyl isomerase 4
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Chromatin
Euchromatin
Heterochromatin
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
PML Body
Protein-containing Complex
Pronucleus
Perinuclear Region Of Cytoplasm
Nuclear Stress Granule
Mitotic Spindle Pole
Protein Folding Chaperone Complex
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Microtubule
Axon
Protein-containing Complex
Cell Projection
Neuronal Cell Body
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Heat Shock Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Hsp90 Protein Binding
Translation Elongation Factor Binding
STAT Family Protein Binding
Sequence-specific Single Stranded DNA Binding
General Transcription Initiation Factor Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
RNA Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
Protein Binding
ATP Binding
GTP Binding
FK506 Binding
Isomerase Activity
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Copper-dependent Protein Binding
Nuclear Glucocorticoid Receptor Binding
Tau Protein Binding
Phosphoprotein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
In Utero Embryonic Development
Embryonic Placenta Development
DNA Repair
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
MRNA Processing
Defense Response
DNA Damage Response
Female Meiotic Nuclear Division
Spermatogenesis
Response To Nutrient
Cell Population Proliferation
Response To Heat
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Response To Activity
Negative Regulation Of Protein-containing Complex Assembly
Response To Estradiol
Response To Lipopolysaccharide
Negative Regulation Of Tumor Necrosis Factor Production
Response To Testosterone
Cellular Response To Heat
Cellular Response To Unfolded Protein
Cellular Response To Potassium Ion
Positive Regulation Of Multicellular Organism Growth
Response To Amino Acid
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
MRNA Transport
Embryonic Process Involved In Female Pregnancy
Positive Regulation Of Stress Granule Assembly
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Amino Acid Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Estradiol Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Radiation
Cellular Response To Gamma Radiation
Cellular Response To Diamide
Negative Regulation Of Inclusion Body Assembly
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cellular Response To Heat
Response To Peptide
Positive Regulation Of Apoptotic DNA Fragmentation
Cellular Response To Sodium Arsenite
Cellular Response To Angiotensin
Cellular Response To Nitroglycerin
Cellular Response To L-glutamine
Response To Hypobaric Hypoxia
Response To Psychosocial Stress
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Apoptotic Signaling Pathway
Protein Folding
Steroid Hormone Receptor Complex Assembly
Copper Ion Transport
Embryo Implantation
Negative Regulation Of Neuron Projection Development
Androgen Receptor Signaling Pathway
Prostate Gland Development
Negative Regulation Of Microtubule Polymerization Or Depolymerization
Negative Regulation Of Microtubule Polymerization
Protein-containing Complex Localization
Male Sex Differentiation
Reproductive Structure Development
Pathways
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Aggrephagy
Mitochondrial unfolded protein response (UPRmt)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
ESR-mediated signaling
Estrogen-dependent gene expression
Potential therapeutics for SARS
Drugs
Bimoclomol
Diseases
GWAS
Dupuytren's disease (
28886342
)
Apolipoprotein A1 levels (
32203549
)
Estradiol levels (
34255042
)
FEV1 (
30804560
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Lung function (FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Quantitative traits (
19197348
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
52 interacting genes:
CAMK2A
CDC20
CDK6
CEBPB
CHST10
CREBBP
CSNK2A1
DAXX
DNAJB1
ENO2
FILIP1
FKBP4
FKBP5
GSK3A
GTF2A2
GTF2B
HSBP1
HSF2
HSP90AA1
HSPA1A
HSPA8
MAPK1
MAPK3
MAPK8
MAPK9
MAPKAPK2
NCOA6
OTUB1
PIM2
PPID
PRKDC
PTGES3
RALBP1
REPS1
RNF20
SMARCA4
STAT1
STUB1
SUB1
SUMO1
SUMO3
SYMPK
TAF1
TAF7
TAF9
TBP
TRRAP
UBC
UBE2I
XRCC5
XRCC6
YWHAE
24 interacting genes:
ACVR1
AHSA1
ATOX1
CALM1
CEBPA
CSNK2A1
EGFR
ESR1
FES
FKBP1A
GLMN
HSF1
HSPA4
IRF4
NR3C1
NR3C2
OGT
PHYH
PTPN2
S100A1
S100A2
S100A6
SH3BP4
SMURF2
Entrez ID
3297
2288
HPRD ID
00778
11794
Ensembl ID
ENSG00000185122
ENSG00000004478
Uniprot IDs
Q00613
Q02790
PDB IDs
2LDU
5D5U
5D5V
5HDG
5HDN
7DCJ
7DCS
7DCT
1N1A
1P5Q
1Q1C
1QZ2
4DRJ
4LAV
4LAW
4LAX
4LAY
4TW8
6RCY
8FFV
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Nucleus
Cellular Response To Heat
Positive Regulation Of Metabolic Process
Regulation Of Protein Stability
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Stabilization
Enzyme Binding
Regulation Of DNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Heat
ATP Binding
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cytosol
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Response To Stress
Transcription Factor TFIID Complex
Protein Serine Kinase Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Preinitiation Complex Assembly
Regulation Of Gene Expression
DNA Damage Response
Heat Shock Protein Binding
Nucleic Acid Metabolic Process
Ubiquitin Protein Ligase Binding
Macromolecule Metabolic Process
RNA Polymerase II General Transcription Initiation Factor Activity
Protein Serine/threonine Kinase Activity
DNA-templated Transcription Initiation
Nucleobase-containing Compound Metabolic Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
RNA Polymerase II Preinitiation Complex Assembly
STAT Family Protein Binding
Hsp90 Protein Binding
Estrogen Response Element Binding
Regulation Of Multicellular Organismal Process
Signal Transduction
ATPase Binding
Cytosol
Calcium-dependent Protein Binding
Protein-containing Complex
Regulation Of Cell Population Proliferation
Embryonic Placenta Development
TBP-class Protein Binding
Steroid Binding
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Signal Transduction
Identical Protein Binding
Intracellular Signal Transduction
Cellular Response To Estradiol Stimulus
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Hemopoiesis
Positive Regulation Of Signal Transduction
Sequence-specific DNA Binding
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Developmental Process
Positive Regulation Of Multicellular Organismal Process
Response To Nutrient
Nuclear Receptor Activity
Regulation Of Gluconeogenesis
Positive Regulation Of Fibroblast Proliferation
Regulation Of Signal Transduction
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Response To Lipid
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Lipid Binding
Regulation Of DNA-templated Transcription
Regulation Of Programmed Cell Death
Regulation Of RNA Biosynthetic Process
Regulation Of Protein Catabolic Process
Regulation Of MiRNA Transcription
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
S100 Protein Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Protein Folding
Response To Hormone
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Tagcloud (Intersection)
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