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HSF1 and DNAJB1
Number of citations of the paper that reports this interaction (PubMedID
9499401
)
64
Data Source:
HPRD
(in vitro)
HSF1
DNAJB1
Description
heat shock transcription factor 1
DnaJ heat shock protein family (Hsp40) member B1
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Chromatin
Euchromatin
Heterochromatin
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
PML Body
Protein-containing Complex
Pronucleus
Perinuclear Region Of Cytoplasm
Nuclear Stress Granule
Mitotic Spindle Pole
Protein Folding Chaperone Complex
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Postsynaptic Density
Neuronal Cell Body
Dendritic Spine
Sperm Head
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Heat Shock Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Hsp90 Protein Binding
Translation Elongation Factor Binding
STAT Family Protein Binding
Sequence-specific Single Stranded DNA Binding
General Transcription Initiation Factor Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
ATPase Activator Activity
Transcription Corepressor Activity
Protein Binding
Hsp70 Protein Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Protein-folding Chaperone Binding
ATPase Binding
Transcription Regulator Inhibitor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
In Utero Embryonic Development
Embryonic Placenta Development
DNA Repair
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
MRNA Processing
Defense Response
DNA Damage Response
Female Meiotic Nuclear Division
Spermatogenesis
Response To Nutrient
Cell Population Proliferation
Response To Heat
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Response To Activity
Negative Regulation Of Protein-containing Complex Assembly
Response To Estradiol
Response To Lipopolysaccharide
Negative Regulation Of Tumor Necrosis Factor Production
Response To Testosterone
Cellular Response To Heat
Cellular Response To Unfolded Protein
Cellular Response To Potassium Ion
Positive Regulation Of Multicellular Organism Growth
Response To Amino Acid
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
MRNA Transport
Embryonic Process Involved In Female Pregnancy
Positive Regulation Of Stress Granule Assembly
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Amino Acid Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Estradiol Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Radiation
Cellular Response To Gamma Radiation
Cellular Response To Diamide
Negative Regulation Of Inclusion Body Assembly
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cellular Response To Heat
Response To Peptide
Positive Regulation Of Apoptotic DNA Fragmentation
Cellular Response To Sodium Arsenite
Cellular Response To Angiotensin
Cellular Response To Nitroglycerin
Cellular Response To L-glutamine
Response To Hypobaric Hypoxia
Response To Psychosocial Stress
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Protein Folding
Response To Unfolded Protein
Forebrain Development
Cellular Response To Heat
Negative Regulation Of Inclusion Body Assembly
Regulation Of Cellular Response To Heat
Positive Regulation Of Protein Folding
Pathways
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Aggrephagy
Mitochondrial unfolded protein response (UPRmt)
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
MAPK6/MAPK4 signaling
Drugs
Bimoclomol
Diseases
GWAS
Dupuytren's disease (
28886342
)
Adventurousness (
30643258
)
General risk tolerance (MTAG) (
30643258
)
Interacting Genes
52 interacting genes:
CAMK2A
CDC20
CDK6
CEBPB
CHST10
CREBBP
CSNK2A1
DAXX
DNAJB1
ENO2
FILIP1
FKBP4
FKBP5
GSK3A
GTF2A2
GTF2B
HSBP1
HSF2
HSP90AA1
HSPA1A
HSPA8
MAPK1
MAPK3
MAPK8
MAPK9
MAPKAPK2
NCOA6
OTUB1
PIM2
PPID
PRKDC
PTGES3
RALBP1
REPS1
RNF20
SMARCA4
STAT1
STUB1
SUB1
SUMO1
SUMO3
SYMPK
TAF1
TAF7
TAF9
TBP
TRRAP
UBC
UBE2I
XRCC5
XRCC6
YWHAE
33 interacting genes:
A2M
AKT1
ANK2
APP
BDKRB1
BRCA1
BRMS1
CEBPA
CENPE
CYP2C8
DNAJC3
DYRK3
ECSIT
FANCA
FANCC
GLB1
GSK3A
HSF1
HSPA1A
MAST1
NQO1
NRAS
PEA15
PLEKHO1
PPDPF
PSEN2
PTGES3
SOD1
SPP1
STUB1
TERF1
TTLL12
ZFP36
Entrez ID
3297
3337
HPRD ID
00778
05198
Ensembl ID
ENSG00000185122
ENSG00000132002
Uniprot IDs
Q00613
P25685
Q6FHS4
PDB IDs
2LDU
5D5U
5D5V
5HDG
5HDN
7DCJ
7DCS
7DCT
1HDJ
2QLD
3AGX
3AGY
3AGZ
4WB7
6BYR
6WJF
6WJG
6Z5N
7NDX
8FE2
8FE5
8FEC
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Nucleus
Cellular Response To Heat
Positive Regulation Of Metabolic Process
Regulation Of Protein Stability
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Stabilization
Enzyme Binding
Regulation Of DNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Heat
ATP Binding
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cytosol
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Response To Stress
Transcription Factor TFIID Complex
Protein Serine Kinase Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Preinitiation Complex Assembly
Regulation Of Gene Expression
DNA Damage Response
Heat Shock Protein Binding
Nucleic Acid Metabolic Process
Ubiquitin Protein Ligase Binding
Macromolecule Metabolic Process
RNA Polymerase II General Transcription Initiation Factor Activity
Protein Serine/threonine Kinase Activity
DNA-templated Transcription Initiation
Nucleobase-containing Compound Metabolic Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
RNA Polymerase II Preinitiation Complex Assembly
Enzyme Binding
Regulation Of Programmed Cell Death
Regulation Of Growth
Regulation Of Apoptotic Process
Intracellular Signal Transduction
Response To Temperature Stimulus
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Heat
Cellular Response To Metal Ion
Protein-folding Chaperone Binding
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Response To Lipid
Regulation Of Developmental Growth
Positive Regulation Of Proteolysis
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Response To Steroid Hormone
Intracellular Signaling Cassette
Misfolded Protein Binding
Positive Regulation Of Macromolecule Metabolic Process
Cytoplasm
Negative Regulation Of Programmed Cell Death
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Cellular Response To Stress
Positive Regulation Of Apoptotic Process
Heat Shock Protein Binding
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Catabolic Process
Response To Peptide
Regulation Of Cell Growth
Protein-containing Complex
Positive Regulation Of Gene Expression
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Cell Growth
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Response To Hormone
Cellular Response To Topologically Incorrect Protein
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Defense Response
Regulation Of Cell Development
Signal Transduction
Regulation Of Cell Cycle
Response To Stress
Regulation Of Cellular Component Organization
Regulation Of Immune System Process
Negative Regulation Of Apoptotic Process
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