HSF1 and GTF2A2

Number of citations of the paper that reports this interaction (PMID 11005381)
9

Data Source:
HPRD (in vitro, in vivo)

		HSF1	GTF2A2
Gene Name		heat shock transcription factor 1	general transcription factor IIA, 2, 12kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein Complex Pronucleus	Nucleoplasm Transcription Factor TFIIA Complex Cell Junction
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Placenta Development Transcription, DNA-templated Protein Phosphorylation Defense Response Female Meiotic Division Spermatogenesis Negative Regulation Of Cell Proliferation Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Heat Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Process Involved In Female Pregnancy Regulation Of Spindle Checkpoint Regulation Of Cellular Response To Heat	Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Pathways		HSF1 activation HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PLK1 PPID PRKDC PTGES3 RALBP1 REPS1 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE	7 interactors: GTF2A1 GTF2A1L GTF2E1 HSF1 TAF4 TBP TBPL1
Entrez ID		3297	2958
HPRD ID		00778	02747
Ensembl ID		ENSG00000185122	ENSG00000140307
Uniprot IDs		Q00613	B2R506 P52657
PDB IDs		2LDU	1NVP
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Cellular Response To Heat Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Heat Viral Process Response To Temperature Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Gene Expression Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Chaperone-mediated Protein Folding Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Gene Expression Innate Immune Response Cellular Protein Modification Process Regulation Of Cellular Process Peptidyl-serine Phosphorylation Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process	DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Viral Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Reproduction Single Organism Reproductive Process Reproductive Process Spermatogenesis Male Gamete Generation Regulation Of Metabolic Process Gamete Generation Developmental Process Involved In Reproduction DTTP Biosynthetic Process Sexual Reproduction Cellular Metabolic Process Embryonic Process Involved In Female Pregnancy Deoxyribonucleotide Biosynthetic Process Acrosome Assembly Chromatin Silencing At RDNA Positive Regulation Of Transcription, DNA-templated Regulation Of Spindle Checkpoint Deoxyribonucleoside Triphosphate Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Termination Of RNA Polymerase I Transcription Positive Regulation Of Gene Expression Transcription Elongation From RNA Polymerase I Promoter Spermatid Nucleus Differentiation Regulation Of Cellular Process
Tagcloud ?		atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream	advance atp5j differs doi erythroleukemia exerts lep lim lipoma lpp m133k march mpn neoplasm npy1r npy5r onc online persistently platelets preferred promoters publication recruit stat5 synergistically thrombopoietin transducer vegfc
Tagcloud (Difference) ?		atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream	advance atp5j differs doi erythroleukemia exerts lep lim lipoma lpp m133k march mpn neoplasm npy1r npy5r onc online persistently platelets preferred promoters publication recruit stat5 synergistically thrombopoietin transducer vegfc
Tagcloud (Intersection) ?