HSF1 and ENO2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSF1	ENO2
Gene Name		heat shock transcription factor 1	enolase 2 (gamma, neuronal)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein Complex Pronucleus	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytosol Plasma Membrane Perikaryon Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Magnesium Ion Binding Phosphopyruvate Hydratase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Placenta Development Transcription, DNA-templated Protein Phosphorylation Defense Response Female Meiotic Division Spermatogenesis Negative Regulation Of Cell Proliferation Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Heat Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Process Involved In Female Pregnancy Regulation Of Spindle Checkpoint Regulation Of Cellular Response To Heat	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Pathogenesis Small Molecule Metabolic Process
Pathways		HSF1 activation HSF1-dependent transactivation Attenuation phase Cellular response to heat stress Regulation of HSF1-mediated heat shock response	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PLK1 PPID PRKDC PTGES3 RALBP1 REPS1 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE	23 interactors: A2M ACD ANXA11 C16orf45 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C
Entrez ID		3297	2026
HPRD ID		00778	00573
Ensembl ID		ENSG00000185122	ENSG00000111674
Uniprot IDs		Q00613	P09104 Q6FHV6
PDB IDs		2LDU	1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Cellular Response To Heat Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Heat Viral Process Response To Temperature Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Abiotic Stimulus Regulation Of Gene Expression Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Chaperone-mediated Protein Folding Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Gene Expression Innate Immune Response Cellular Protein Modification Process Regulation Of Cellular Process Peptidyl-serine Phosphorylation Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Replication Regulation Of Telomerase Activity Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Telomerase Activity Mitotic Cell Cycle Process Organelle Organization Cell Division Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Platelet Degranulation Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Cell Cycle Positive Regulation Of DNA Biosynthetic Process Cellular Component Assembly G2/M Transition Of Mitotic Cell Cycle RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Exocytosis Cell Cycle Process Positive Regulation Of DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Organelle Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Catalytic Activity Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Platelet Activation Cellular Localization Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Protein ADP-ribosylation
Tagcloud ?		atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream	begin differentially dige enolase failures gondii gra7 hypothetical imc1 mic2 naturally parasite proteomics pyrimethamine qrt rh rhoptry rop2 rop2a spectrometer spots strains sulfadiazine sulfonamide tga tgh toxoplasma toxoplasmosis undertook
Tagcloud (Difference) ?		atg cloned codon composed consensus contiguous derivatives dnaj element ends extension footprinting gaan heat homologue hse hses hsp40 intron minimal mobility motifs primer race sequences shock supershift transcripts upstream	begin differentially dige enolase failures gondii gra7 hypothetical imc1 mic2 naturally parasite proteomics pyrimethamine qrt rh rhoptry rop2 rop2a spectrometer spots strains sulfadiazine sulfonamide tga tgh toxoplasma toxoplasmosis undertook
Tagcloud (Intersection) ?