HSF1

Description		heat shock transcription factor 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Euchromatin Heterochromatin Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton PML Body Protein-containing Complex Pronucleus Perinuclear Region Of Cytoplasm Nuclear Stress Granule Mitotic Spindle Pole Protein Folding Chaperone Complex Ribonucleoprotein Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Heat Shock Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding Translation Elongation Factor Binding STAT Family Protein Binding Sequence-specific Single Stranded DNA Binding General Transcription Initiation Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development Embryonic Placenta Development DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Defense Response DNA Damage Response Female Meiotic Nuclear Division Spermatogenesis Response To Nutrient Cell Population Proliferation Response To Heat Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Activity Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Cellular Response To Heat Cellular Response To Unfolded Protein Cellular Response To Potassium Ion Positive Regulation Of Multicellular Organism Growth Response To Amino Acid Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation MRNA Transport Embryonic Process Involved In Female Pregnancy Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Radiation Cellular Response To Gamma Radiation Cellular Response To Diamide Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cellular Response To Heat Response To Peptide Positive Regulation Of Apoptotic DNA Fragmentation Cellular Response To Sodium Arsenite Cellular Response To Angiotensin Cellular Response To Nitroglycerin Cellular Response To L-glutamine Response To Hypobaric Hypoxia Response To Psychosocial Stress Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy Mitochondrial unfolded protein response (UPRmt)
Drugs		Bimoclomol
Diseases
GWAS		Dupuytren's disease ( 28886342)
Novel Interacting Genes		1 novel interacting genes: LY6E
Interacting Genes		52 interacting genes: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSP90AA1 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 OTUB1 PIM2 PPID PRKDC PTGES3 RALBP1 REPS1 RNF20 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP TRRAP UBC UBE2I XRCC5 XRCC6 YWHAE
Entrez ID		3297
HPRD ID		00778
Ensembl ID		ENSG00000185122
Uniprot IDs		Q00613
PDB IDs		2LDU 5D5U 5D5V 5HDG 5HDN 7DCJ 7DCS 7DCT
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stress Nucleus Cellular Response To Heat Positive Regulation Of Metabolic Process Regulation Of Protein Stability Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Stabilization Enzyme Binding Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Heat ATP Binding Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytosol Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Transcription Factor TFIID Complex Protein Serine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Preinitiation Complex Assembly Regulation Of Gene Expression DNA Damage Response Heat Shock Protein Binding Nucleic Acid Metabolic Process Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Protein Serine/threonine Kinase Activity DNA-templated Transcription Initiation Nucleobase-containing Compound Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II Preinitiation Complex Assembly
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