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HSF1 and SUB1
Number of citations of the paper that reports this interaction (PubMedID
11005381
)
47
Data Source:
HPRD
(in vitro)
HSF1
SUB1
Description
heat shock transcription factor 1
SUB1 regulator of transcription
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Kinetochore
Chromatin
Euchromatin
Heterochromatin
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
PML Body
Protein-containing Complex
Pronucleus
Perinuclear Region Of Cytoplasm
Nuclear Stress Granule
Mitotic Spindle Pole
Protein Folding Chaperone Complex
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Extracellular Exosome
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Heat Shock Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Hsp90 Protein Binding
Translation Elongation Factor Binding
STAT Family Protein Binding
Sequence-specific Single Stranded DNA Binding
General Transcription Initiation Factor Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
In Utero Embryonic Development
Embryonic Placenta Development
DNA Repair
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
MRNA Processing
Defense Response
DNA Damage Response
Female Meiotic Nuclear Division
Spermatogenesis
Response To Nutrient
Cell Population Proliferation
Response To Heat
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Response To Activity
Negative Regulation Of Protein-containing Complex Assembly
Response To Estradiol
Response To Lipopolysaccharide
Negative Regulation Of Tumor Necrosis Factor Production
Response To Testosterone
Cellular Response To Heat
Cellular Response To Unfolded Protein
Cellular Response To Potassium Ion
Positive Regulation Of Multicellular Organism Growth
Response To Amino Acid
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
MRNA Transport
Embryonic Process Involved In Female Pregnancy
Positive Regulation Of Stress Granule Assembly
Protein-containing Complex Assembly
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Amino Acid Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Estradiol Stimulus
Cellular Response To Xenobiotic Stimulus
Cellular Response To Radiation
Cellular Response To Gamma Radiation
Cellular Response To Diamide
Negative Regulation Of Inclusion Body Assembly
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cellular Response To Heat
Response To Peptide
Positive Regulation Of Apoptotic DNA Fragmentation
Cellular Response To Sodium Arsenite
Cellular Response To Angiotensin
Cellular Response To Nitroglycerin
Cellular Response To L-glutamine
Response To Hypobaric Hypoxia
Response To Psychosocial Stress
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Positive Regulation Of Apoptotic Signaling Pathway
RNA Polymerase II Promoter Clearance
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA Metabolic Process
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Aggrephagy
Mitochondrial unfolded protein response (UPRmt)
Drugs
Bimoclomol
Diseases
GWAS
Dupuytren's disease (
28886342
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Interacting Genes
52 interacting genes:
CAMK2A
CDC20
CDK6
CEBPB
CHST10
CREBBP
CSNK2A1
DAXX
DNAJB1
ENO2
FILIP1
FKBP4
FKBP5
GSK3A
GTF2A2
GTF2B
HSBP1
HSF2
HSP90AA1
HSPA1A
HSPA8
MAPK1
MAPK3
MAPK8
MAPK9
MAPKAPK2
NCOA6
OTUB1
PIM2
PPID
PRKDC
PTGES3
RALBP1
REPS1
RNF20
SMARCA4
STAT1
STUB1
SUB1
SUMO1
SUMO3
SYMPK
TAF1
TAF7
TAF9
TBP
TRRAP
UBC
UBE2I
XRCC5
XRCC6
YWHAE
24 interacting genes:
ADAP1
APP
CBX5
CEBPA
CSNK2A1
CSTF2
EP300
GTF2A1L
HNF4A
HSF1
OTUD5
PCNA
POLR2A
POLR2B
POU2AF1
PSIP1
RCOR1
REST
RNF10
SDCBP
SP1
TAF1
TBP
TP53
Entrez ID
3297
10923
HPRD ID
00778
02737
Ensembl ID
ENSG00000185122
ENSG00000113387
Uniprot IDs
Q00613
P53999
Q6IBA2
PDB IDs
2LDU
5D5U
5D5V
5HDG
5HDN
7DCJ
7DCS
7DCT
1PCF
2C62
2PHE
4USG
6YCS
7E4W
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Cellular Response To Stress
Nucleus
Cellular Response To Heat
Positive Regulation Of Metabolic Process
Regulation Of Protein Stability
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Stabilization
Enzyme Binding
Regulation Of DNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Heat
ATP Binding
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cytosol
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Response To Stress
Transcription Factor TFIID Complex
Protein Serine Kinase Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Preinitiation Complex Assembly
Regulation Of Gene Expression
DNA Damage Response
Heat Shock Protein Binding
Nucleic Acid Metabolic Process
Ubiquitin Protein Ligase Binding
Macromolecule Metabolic Process
RNA Polymerase II General Transcription Initiation Factor Activity
Protein Serine/threonine Kinase Activity
DNA-templated Transcription Initiation
Nucleobase-containing Compound Metabolic Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Negative Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
RNA Polymerase II Preinitiation Complex Assembly
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin Binding
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Transcription Cis-regulatory Region Binding
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription Repressor Complex
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
RNA Metabolic Process
Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
STAT Family Protein Binding
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Nucleic Acid Metabolic Process
Chromatin Organization
Rhythmic Process
Euchromatin
MRNA Transcription
Negative Regulation Of Macromolecule Metabolic Process
Cellular Response To Xenobiotic Stimulus
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Positive Regulation Of DNA-templated Transcription Initiation
Cellular Response To Radiation
DNA-binding Transcription Factor Binding
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