HSF1 and MAPK8

Number of citations of the paper that reports this interaction (PubMedID 10747973)
0

Data Source:
HPRD (in vitro, in vivo)

		HSF1	MAPK8
Description		heat shock transcription factor 1	mitogen-activated protein kinase 8
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Euchromatin Heterochromatin Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton PML Body Protein-containing Complex Pronucleus Perinuclear Region Of Cytoplasm Nuclear Stress Granule Mitotic Spindle Pole Protein Folding Chaperone Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Axon Synapse Basal Dendrite
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Heat Shock Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Hsp90 Protein Binding Translation Elongation Factor Binding STAT Family Protein Binding Sequence-specific Single Stranded DNA Binding General Transcription Initiation Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Phosphatase Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development Embryonic Placenta Development DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Defense Response DNA Damage Response Female Meiotic Nuclear Division Spermatogenesis Response To Nutrient Cell Population Proliferation Response To Heat Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Activity Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Cellular Response To Heat Cellular Response To Unfolded Protein Cellular Response To Potassium Ion Positive Regulation Of Multicellular Organism Growth Response To Amino Acid Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation MRNA Transport Embryonic Process Involved In Female Pregnancy Positive Regulation Of Stress Granule Assembly Protein-containing Complex Assembly Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Radiation Cellular Response To Gamma Radiation Cellular Response To Diamide Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cellular Response To Heat Response To Peptide Positive Regulation Of Apoptotic DNA Fragmentation Cellular Response To Sodium Arsenite Cellular Response To Angiotensin Cellular Response To Nitroglycerin Cellular Response To L-glutamine Response To Hypobaric Hypoxia Response To Psychosocial Stress Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Apoptotic Signaling Pathway	MAPK Cascade Double-strand Break Repair Protein Phosphorylation Response To Oxidative Stress JNK Cascade JUN Phosphorylation Response To UV Response To Mechanical Stimulus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Cyclase Activity Positive Regulation Of Cell Killing Negative Regulation Of Protein Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability NLRP3 Inflammasome Complex Assembly Rhythmic Process Positive Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade MRNA Destabilization Protein Poly-ADP-ribosylation Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Senescence Energy Homeostasis Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Localization To Site Of Double-strand Break
Pathways		Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy Mitochondrial unfolded protein response (UPRmt)	Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria NRAGE signals death through JNK NRAGE signals death through JNK NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-38 signaling WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants
Drugs		Bimoclomol	Tamoxifen Minocycline Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Halicin
Diseases
GWAS		Dupuytren's disease ( 28886342)	Blood protein levels in cardiovascular risk ( 28369058) Daytime sleep phenotypes ( 27126917) Opioid dependence (time to event) ( 34124712) Refractive error ( 32231278)
Interacting Genes		52 interacting genes: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSP90AA1 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 OTUB1 PIM2 PPID PRKDC PTGES3 RALBP1 REPS1 RNF20 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP TRRAP UBC UBE2I XRCC5 XRCC6 YWHAE	140 interacting genes: AIMP1 AKT1 APBB2 APLP2 APP ATF2 ATM BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 EEF2K EGFR ELK1 ELK3 ELK4 ELP1 EP300 ETV1 FAM193B FZR1 GANAB GARS1 GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A1 H2AX HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K2 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MBP METTL3 MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NFE2L2 NKAPD1 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCA SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219 ZNF605
Entrez ID		3297	5599
HPRD ID		00778	03100
Ensembl ID		ENSG00000185122	ENSG00000107643
Uniprot IDs		Q00613	A1L4K2 P45983
PDB IDs		2LDU 5D5U 5D5V 5HDG 5HDN 7DCJ 7DCS 7DCT	1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD 4UX9 4YR8 5LW1 6F5E 6ZR5 8PT8 8PT9 8PTA 8R5E 8X5M 9FT9
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Cellular Response To Stress Nucleus Cellular Response To Heat Positive Regulation Of Metabolic Process Regulation Of Protein Stability Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Stabilization Enzyme Binding Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Heat ATP Binding Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytosol Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Transcription Factor TFIID Complex Protein Serine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Preinitiation Complex Assembly Regulation Of Gene Expression DNA Damage Response Heat Shock Protein Binding Nucleic Acid Metabolic Process Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Protein Serine/threonine Kinase Activity DNA-templated Transcription Initiation Nucleobase-containing Compound Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II Preinitiation Complex Assembly	Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Signal Transduction MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Stress Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Cellular Developmental Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Response To Growth Factor Regulation Of Signaling Cellular Response To Oxygen-containing Compound Regulation Of Cell Communication Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Transcription By RNA Polymerase II Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Hormone Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Programmed Cell Death Cell Death Regulation Of Cell Differentiation
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