ZNF133 and ILK

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ZNF133	ILK
Gene Name		zinc finger protein 133	integrin-linked kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Stress Fiber Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Cell Junction Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft Protein Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Signal Transducer Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Extracellular Fibril Organization Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Protein Heterooligomerization Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Generic Transcription Pathway	Cell junction organization Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: FOS ILK KRTAP10-7 MAPK6 MDM2 PDPK1 TRIM28	35 interactors: AKT1 CASP8 CASP9 CAV1 CKB GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		7692	3611
HPRD ID		04964	03842
Ensembl ID		ENSG00000125846	ENSG00000166333
Uniprot IDs		P52736	B7Z1I0 B7Z418 Q13418
PDB IDs			2KBX 3F6Q 3IXE 3KMU 3KMW 3REP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Phosphorylation Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Transport Fc Receptor Signaling Pathway Negative Regulation Of Muscle Cell Apoptotic Process Peptidyl-amino Acid Modification Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cellular Metabolic Process DNA Methylation Regulation Of Intracellular Transport Immune Response Protein Phosphorylation Defense Response Immune Response-regulating Signaling Pathway Phosphate-containing Compound Metabolic Process DNA Modification Positive Regulation Of Gene Expression Cellular Protein Modification Process Cellular Response To UV-C Cellular Response To Vitamin B1 Cellular Response To Reactive Oxygen Species Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of Nucleocytoplasmic Transport Response To Growth Factor Positive Regulation Of Metabolic Process Response To Stress Tissue Development Regulation Of Response To DNA Damage Stimulus Regulation Of Establishment Of Protein Localization Cellular Response To Stimulus Negative Regulation Of DNA Demethylation Phosphatidylinositol-mediated Signaling Cellular Component Assembly Positive Regulation Of Transport Negative Regulation Of Catalytic Activity Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Cell-matrix Adhesion Response To Organonitrogen Compound Negative Regulation Of Cellular Metabolic Process	Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Junction Assembly Cell-substrate Adhesion Response To Growth Factor Positive Regulation Of Signal Transduction Cell-matrix Adhesion Cytoskeleton Organization Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Immune System Process Actin Filament-based Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Heterotypic Cell-cell Adhesion Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Reorganization Single Organismal Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Epithelial Cell Proliferation Cell Migration Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Morphogenesis Angiogenesis Response To Fibroblast Growth Factor Cell Motility Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		11p15 19q13 1p36 20p11 3q21 7q11 7q21 alagille beckwith chromosomally deleted gli krab kruppel q22 shfd1 split straightforward wiedemann williams znf148 znf151 znfs	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Difference) ?		11p15 19q13 1p36 20p11 3q21 7q11 7q21 alagille beckwith chromosomally deleted gli krab kruppel q22 shfd1 split straightforward wiedemann williams znf148 znf151 znfs	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Intersection) ?