MIPEP and ILK

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MIPEP	ILK
Gene Name		mitochondrial intermediate peptidase	integrin-linked kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Stress Fiber Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Sarcomere Lamellipodium Cell Junction Neuronal Cell Body Costamere Terminal Bouton Dendritic Shaft Protein Complex
	Molecular Function	Metalloendopeptidase Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity Signal Transducer Activity Integrin Binding Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion	Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cell-matrix Adhesion Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Aging Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Negative Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Nerve Development Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Myelin Assembly Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phosphorylation Extracellular Fibril Organization Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Projection Morphogenesis Positive Regulation Of Dendrite Morphogenesis Protein Heterooligomerization Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			Cell junction organization Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Lung cancer ( 21725308) Myopia (pathological) ( 21640322) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		2 interactors: ILK MAPK6	35 interactors: AKT1 CASP8 CASP9 CAV1 CKB GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MIPEP NCK2 NOTCH1 PARVA PARVB PARVG PDPK1 PPP1R12A PXN RICTOR RNF19A RPL13 SERPINA4 SHC1 SNRNP35 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		4285	3611
HPRD ID		03761	03842
Ensembl ID		ENSG00000027001	ENSG00000166333
Uniprot IDs		Q99797	B7Z1I0 B7Z418 Q13418
PDB IDs			2KBX 3F6Q 3IXE 3KMU 3KMW 3REP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Fibroblast Migration Extracellular Fibril Organization Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Myoblast Differentiation Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Myelin Assembly Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Protein Phosphorylation Platelet Aggregation Cell Cycle Protein Kinase B Signaling Positive Regulation Of Axon Extension Regulation Of Myoblast Differentiation Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Proliferation Substrate Adhesion-dependent Cell Spreading Myelination In Peripheral Nervous System Schwann Cell Development Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Dendrite Development Branching Involved In Ureteric Bud Morphogenesis Schwann Cell Differentiation Ureteric Bud Morphogenesis Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis Cell Aging Positive Regulation Of Osteoblast Differentiation Phosphorylation Intracellular Signal Transduction Positive Regulation Of Axonogenesis Positive Regulation Of Protein Kinase B Signaling Nephron Morphogenesis Regulation Of BMP Signaling Pathway Renal Tubule Morphogenesis Positive Regulation Of Muscle Cell Differentiation Nerve Development Positive Regulation Of Ossification Renal Tubule Development Regulation Of Smooth Muscle Cell Proliferation Kidney Morphogenesis Glial Cell Development Regulation Of Dendrite Development Peripheral Nervous System Development	Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Junction Assembly Cell-substrate Adhesion Response To Growth Factor Positive Regulation Of Signal Transduction Cell-matrix Adhesion Cytoskeleton Organization Regulation Of Cellular Amino Acid Metabolic Process Cell Adhesion Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Organization Regulation Of Cell Adhesion Regulation Of Immune System Process Actin Filament-based Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Heterotypic Cell-cell Adhesion Regulation Of Cellular Protein Metabolic Process Actin Cytoskeleton Reorganization Single Organismal Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Blood Coagulation Wound Healing Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Epithelial Cell Proliferation Cell Migration Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Morphogenesis Angiogenesis Response To Fibroblast Growth Factor Cell Motility Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		13q12 as1 blindness c1qtnf9b chinese cohorts disequilibrium extremely eye gwas han heterozygous homozygous ld linkage myopia odds pigment proved retina retinal rpe rs1886970 rs3794338 rs7325450 rs7331047 rs9318086 rs9510902 snps	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Difference) ?		13q12 as1 blindness c1qtnf9b chinese cohorts disequilibrium extremely eye gwas han heterozygous homozygous ld linkage myopia odds pigment proved retina retinal rpe rs1886970 rs3794338 rs7325450 rs7331047 rs9318086 rs9510902 snps	bird cb11b cd18 chicks conferred eliminate enteritidis hatch heterophilic heterophils immaturity immunopotentiation initiates integrins kill lymphokines migrate phagocytic phagocytize phagocytosis posthatch poultry poults propria salmonella selectins turkey unfortunately vigorous
Tagcloud (Intersection) ?