MIPEP and ILK

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MIPEP	ILK
Description		mitochondrial intermediate peptidase	integrin linked kinase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Sarcomere Lamellipodium Cell Projection Anchoring Junction
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Proteolysis Peptide Metabolic Process Protein Processing Involved In Protein Targeting To Mitochondrion	Cell Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Mitotic Spindle Organization Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Fibroblast Migration Schwann Cell Development Nerve Development Myelination In Peripheral Nervous System Cell Projection Organization Cell Differentiation Positive Regulation Of BMP Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Neural Precursor Cell Proliferation Platelet Aggregation Caveola Assembly Protein Localization To Cell Cortex Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Fourth ventricle volume ( 31530798) Lung cancer ( 21725308) Myopia (pathological) ( 21640322) Venous thromboembolism ( 32232851) Visceral adipose tissue adjusted for BMI ( 22589738)	Malaria ( 31844061)
Interacting Genes		2 interacting genes: ILK MAPK6	43 interacting genes: AKT1 CASP8 CASP9 CAV1 CEBPA CKB FERMT1 FERMT2 FERMT3 GSK3B ILKAP ITGB1 ITGB2 ITGB3 LIMS1 LIMS2 MATK MBP MIPEP NCK2 NOTCH1 OGT PARVA PARVB PARVG PDPK1 PPP1R12A PTPN11 PXN RNF19A RPL13 SERPINA4 SHC1 SNRNP35 SUMO2 TMSB4X TRIM27 TWF2 ZBTB48 ZNF133 ZNF205 ZNF579 ZNF746
Entrez ID		4285	3611
HPRD ID		03761	03842
Ensembl ID		ENSG00000027001	ENSG00000166333
Uniprot IDs		Q99797	Q13418 V9HWF0
PDB IDs			2KBX 3F6Q 3IXE 3KMU 3KMW 3REP 4HI8 4HI9 6MIB
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway ATP Binding Positive Regulation Of Developmental Process Protein Localization To Cell Cortex Septin Cytoskeleton Nucleotide Binding Tube Morphogenesis Hyaloid Vascular Plexus Regression Vascular Endothelial Growth Factor Receptor Activity Protein Phosphorylation Actin Cytoskeleton Phosphorylation Focal Adhesion Plasma Membrane Raft Assembly Protein Serine/threonine Kinase Activity Caveola Assembly Negative Regulation Of Vascular Endothelial Cell Proliferation Protein Kinase Binding Anatomical Structure Regression Membrane Raft Assembly Plasma Membrane Raft Organization Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Developmental Process Schwann Cell Development Fibroblast Migration Myelination In Peripheral Nervous System MAP Kinase Activity Kinase Activity Monocyte Chemotaxis Negative Regulation Of Neural Precursor Cell Proliferation Membrane Raft Organization Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAP Kinase Activity Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Cell Proliferation Growth Factor Binding Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Migration Peptidyl-tyrosine Phosphorylation Branching Involved In Ureteric Bud Morphogenesis Nerve Development Intracellular Signaling Cassette Establishment Or Maintenance Of Apical/basal Cell Polarity Platelet Aggregation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Focal Adhesion Cell-substrate Adhesion Anchoring Junction Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Migration Protein Kinase Binding Positive Regulation Of Cell Motility Cell Surface Receptor Signaling Pathway Positive Regulation Of Locomotion Cellular Response To Growth Factor Stimulus Positive Regulation Of Proteolysis Regulation Of Cellular Localization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Developmental Process Response To Growth Factor Positive Regulation Of Biosynthetic Process Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell-substrate Adhesion ERBB Signaling Pathway Regulation Of Locomotion Integrin Binding Heterotypic Cell-cell Adhesion Negative Regulation Of Developmental Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Actin Binding Regulation Of Actin Filament-based Process Regulation Of Proteolysis Positive Regulation Of Cellular Component Biogenesis T Cell Costimulation Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin
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