ARHGDIA and HAAO

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		ARHGDIA	HAAO
Description		Rho GDP dissociation inhibitor alpha	3-hydroxyanthranilate 3,4-dioxygenase
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GO Annotations	Cellular Component	Immunological Synapse Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse	Cytoplasm Cytosol
	Molecular Function	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding	3-hydroxyanthranilate 3,4-dioxygenase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Rho Protein Signal Transduction Regulation Of Protein Localization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Semaphorin-plexin Signaling Pathway Regulation Of Synaptic Vesicle Cycle	L-tryptophan Catabolic Process NAD+ Biosynthetic Process Response To Zinc Ion Pyridine Nucleotide Biosynthetic Process Quinolinate Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Anthranilate Metabolic Process Dicarboxylic Acid Metabolic Process Response To Cadmium Ion Quinolinate Metabolic Process Neuron Cellular Homeostasis
Pathways		Axonal growth inhibition (RHOA activation) Axonal growth stimulation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle	Tryptophan catabolism
Drugs
Diseases
GWAS			Birth weight ( 31043758) Breastfeeding duration ( 25475840) Diastolic blood pressure ( 27841878) Glucose homeostasis traits ( 25524916) Hypospadias ( 25108383) Mean spheric corpuscular volume ( 32888494) Retinitis pigmentosa ( 33514863) Systolic blood pressure ( 27841878 28739976) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B CEBPA EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1	4 interacting genes: ARHGDIA GAD1 POT1 TERF2IP
Entrez ID		396	23498
HPRD ID		03565	05158
Ensembl ID		ENSG00000141522	ENSG00000162882
Uniprot IDs		J3QQX2 P52565 V9HWE8	P46952
PDB IDs		1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80 8X8T	2QNK 5TK5 5TKQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Catabolic Process Negative Regulation Of Cellular Component Organization Cellular Response To Stress Erythrocyte Enucleation Regulation Of Primary Metabolic Process Actin Filament Organization Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Shelterin Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cytoskeleton Organization Post-translational Protein Modification Response To Stress Positive Regulation Of Metabolic Process Protein Modification Process Macromolecule Catabolic Process Positive Regulation Of Lamellipodium Assembly Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Developmental Process Negative Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Nuclear Telomere Cap Complex Positive Regulation Of Developmental Process Positive Regulation Of Lamellipodium Organization Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Lamellipodium Assembly Fibroblast Apoptotic Process Positive Regulation Of Cell Adhesion Regulation Of Macromolecule Biosynthetic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament-based Process Telomere Capping Regulation Of Metabolic Process Small GTPase-mediated Signal Transduction Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Signaling Cassette	Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Telomere Organization Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Negative Regulation Of DNA Metabolic Process Positive Regulation Of Telomeric Loop Disassembly Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination At Telomere Rho GDP-dissociation Inhibitor Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Chromosome, Telomeric Region Telomeric D-loop Binding Telomere Assembly Regulation Of DNA Repair Single-stranded Telomeric DNA Binding Regulation Of Chromosome Organization Gamma-aminobutyric Acid Biosynthetic Process Succinate Metabolic Process Telomerase Inhibitor Activity Positive Regulation Of DNA Metabolic Process Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane DEAD/H-box RNA Helicase Binding Carbon-carbon Lyase Activity Telomeric D-loop Disassembly Chromosome Organization Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Inhibitory Synapse
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