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PRKCI and PARD6A
Number of citations of the paper that reports this interaction (PubMedID
11260256
)
0
Data Source:
HPRD
(two hybrid, in vitro)
PRKCI
PARD6A
Description
protein kinase C iota
par-6 family cell polarity regulator alpha
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Brush Border
Bicellular Tight Junction
Cilium
Microtubule Cytoskeleton
Membrane
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Apical Part Of Cell
Extracellular Exosome
Tight Junction
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
PAR Polarity Complex
Ruffle
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Plasma Membrane
Bicellular Tight Junction
Cell Cortex
Membrane
Apical Plasma Membrane
Centriolar Satellite
Cell Projection
Tight Junction
Anchoring Junction
PAR Polarity Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Phospholipid Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Protein Binding
GTP-dependent Protein Binding
Small GTPase Binding
Biological Process
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Establishment Of Cell Polarity
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of D-glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Cellular Response To Chemical Stress
Response To Interleukin-1
Protein Localization To Plasma Membrane
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Centrosome Cycle
Establishment Or Maintenance Of Cell Polarity
Viral Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Maintenance
Positive Regulation Of Protein Secretion
Cell Division
Regulation Of Cellular Localization
Positive Regulation Of Protein Localization To Centrosome
Pathways
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
KEAP1-NFE2L2 pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions
Asymmetric localization of PCP proteins
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOU GTPase cycle
RHOV GTPase cycle
Drugs
Tamoxifen
Staurosporine
Bisindolylmaleimide I
Dequalinium
Benzoyl peroxide
Fostamatinib
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31511532
31630189
)
Obesity-related traits (
23251661
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
51 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
27 interacting genes:
APP
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
PTPN21
RAC1
RHOQ
SNCA
TCP10L3
TGFBR1
WDR83
YWHAH
YWHAZ
Entrez ID
5584
50855
HPRD ID
02105
06316
Ensembl ID
ENSG00000163558
ENSG00000102981
Uniprot IDs
P41743
Q9NPB6
PDB IDs
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
8R3X
8R3Y
1WMH
Enriched GO Terms of Interacting Partners
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Cytoplasm
Cytosol
Intracellular Signaling Cassette
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Localization
Intracellular Signal Transduction
Immune System Process
PAR Polarity Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Regulation Of Protein Localization
Positive Regulation Of Biosynthetic Process
Regulation Of Multicellular Organismal Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Regulation Of Gene Expression
Positive Regulation Of Protein Localization
Regulation Of Immune Response
Plasma Membrane
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Projection Organization
Regulation Of Programmed Cell Death
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Organelle Organization
Negative Regulation Of Programmed Cell Death
Protein Serine/threonine Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Immune System Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Apoptotic Process
Establishment Or Maintenance Of Cell Polarity
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Cell Projection Organization
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Regulation Of Primary Metabolic Process
Regulation Of Innate Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Establishment Or Maintenance Of Apical/basal Cell Polarity
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Establishment Or Maintenance Of Cell Polarity
Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Bicellular Tight Junction
PAR Polarity Complex
Positive Regulation Of Cellular Component Organization
Establishment Of Cell Polarity
Cell-cell Junction Organization
Diacylglycerol-dependent Serine/threonine Kinase Activity
Cell Junction Organization
Cell-cell Junction
Regulation Of Cell Projection Organization
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Cell Projection Organization
Regulation Of Cytoskeleton Organization
Regulation Of Organelle Organization
Protein Serine/threonine Kinase Activity
Apical Part Of Cell
Signal Transduction
Positive Regulation Of Protein Localization
Cell Cortex
Tight Junction
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Synaptic Plasticity
Regulation Of Protein Localization
Protein Kinase Activity
Regulation Of Developmental Process
Protein Phosphorylation
Positive Regulation Of Cellular Component Biogenesis
Protein Serine Kinase Activity
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Programmed Cell Death
Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly
Phosphorylation
GBD Domain Binding
Regulation Of Cell Communication
Regulation Of Signaling
Anchoring Junction
Kinase Activity
Negative Regulation Of Apoptotic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cytoplasm
Supramolecular Fiber Organization
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Filopodium Assembly
Postsynaptic Cytosol
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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