PRKCI and SMG1

Number of citations of the paper that reports this interaction (PMID 8524286)
27

Data Source:
HPRD (two hybrid, in vitro)

		PRKCI	SMG1
Gene Name		protein kinase C, iota	SMG1 phosphatidylinositol 3-kinase-related kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Tight Junction Microtubule Cytoskeleton Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Protein Complex Intercellular Bridge Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Phospholipid Binding Protein Domain Specific Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding Metal Ion Binding Protein Dimerization Activity
	Biological Process	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Cellular Response To Insulin Stimulus Cell Junction Assembly Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Glucose Import Secretion Neurotrophin TRK Receptor Signaling Pathway Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Response To Interleukin-1 Tight Junction Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Double-strand Break Repair Via Homologous Recombination MRNA Export From Nucleus Response To Stress Gene Expression Peptidyl-serine Phosphorylation Protein Autophosphorylation Phosphatidylinositol Phosphorylation
Pathways		Cell junction organization Cell-cell junction organization Signalling by NGF p75NTR recruits signalling complexes Tight junction interactions p75NTR signals via NF-kB p75 NTR receptor-mediated signalling	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: ADAP1 ANXA1 APP BAD CASP8 CDC42 CDK7 CHUK FABP4 FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MARK4 MBP NFKBIA PARD3 PARD6A PARD6B PARD6G PDPK1 PNMA1 RAB2A RAB4A RAC1 RHOQ SMG1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ	8 interactors: CDH5 PRKCI SMAD9 SMG5 SMG8 UPF1 UPF2 UPF3A
Entrez ID		5584	23049
HPRD ID		02105	06123
Ensembl ID		ENSG00000163558	ENSG00000157106
Uniprot IDs		P41743	Q96Q15
PDB IDs		1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Defense Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Immune Response Regulation Of Cell Death Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune System Process Response To Stress Response To Stimulus Intracellular Signal Transduction Signaling Cellular Response To Organic Substance Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Positive Regulation Of Programmed Cell Death Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Death Positive Regulation Of Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Toll-like Receptor 3 Signaling Pathway Apoptotic Process Response To Fibroblast Growth Factor Negative Regulation Of Cell Death	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Transport RNA Transport RNA Localization Aromatic Compound Catabolic Process MRNA Metabolic Process Nucleocytoplasmic Transport Nuclear Transport MRNA Export From Nucleus RNA Export From Nucleus Cellular Macromolecule Catabolic Process Nuclear Export Cytoplasmic Transport Intracellular Transport Catabolic Process RNA Metabolic Process Establishment Of Localization In Cell Gene Expression Cellular Localization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Junction Assembly Cell-cell Junction Organization Establishment Of Apical/basal Cell Polarity Mullerian Duct Regression Enzyme Linked Receptor Protein Signaling Pathway Nitrogen Compound Metabolic Process Histone MRNA Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Monopolar Cell Polarity Blood Vessel Maturation Regulation Of Translation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Translational Termination Dosage Compensation Golgi Vesicle Budding Positive Regulation Of Glial Cell Proliferation Anatomical Structure Regression Histone MRNA Metabolic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse	acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor
Tagcloud (Difference) ?		abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse	acts aml antagonistically aza belongs decay decitabine demethylating deoxycytidine epigenetic genitalia hand hypermethylated hypermethylation hypoxic interference maybe member methylation morphogenetic mtor negatively none nonsense phosphoinositide readily restoring reversing suppressor
Tagcloud (Intersection) ?