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PRKCI and SMG1
Number of citations of the paper that reports this interaction (PubMedID
8524286
)
39
Data Source:
HPRD
(two hybrid, in vitro)
PRKCI
SMG1
Description
protein kinase C iota
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Brush Border
Bicellular Tight Junction
Cilium
Microtubule Cytoskeleton
Membrane
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Apical Part Of Cell
Extracellular Exosome
Tight Junction
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
PAR Polarity Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Chromatoid Body
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Phospholipid Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Telomeric DNA Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Establishment Of Cell Polarity
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of D-glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Cellular Response To Chemical Stress
Response To Interleukin-1
Protein Localization To Plasma Membrane
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
DNA Repair
MRNA Export From Nucleus
DNA Damage Response
Peptidyl-serine Phosphorylation
Regulation Of Telomere Maintenance
Protein Autophosphorylation
Phosphatidylinositol Phosphate Biosynthetic Process
Pathways
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
KEAP1-NFE2L2 pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Tamoxifen
Staurosporine
Bisindolylmaleimide I
Dequalinium
Benzoyl peroxide
Fostamatinib
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31511532
31630189
)
Health literacy (
31250787
)
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Interacting Genes
51 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
10 interacting genes:
CDH5
PRKCI
RNF10
SMAD9
SMG5
SMG8
SNAPIN
UPF1
UPF2
UPF3A
Entrez ID
5584
23049
HPRD ID
02105
06123
Ensembl ID
ENSG00000163558
ENSG00000157106
Uniprot IDs
P41743
Q96Q15
PDB IDs
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
8R3X
8R3Y
6L53
6L54
6SYT
6Z3R
7PW4
7PW5
7PW6
7PW7
7PW8
7PW9
Enriched GO Terms of Interacting Partners
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Cytoplasm
Cytosol
Intracellular Signaling Cassette
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cellular Localization
Intracellular Signal Transduction
Immune System Process
PAR Polarity Complex
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Signal Transduction
Regulation Of Protein Localization
Positive Regulation Of Biosynthetic Process
Regulation Of Multicellular Organismal Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Response To Stress
Regulation Of Gene Expression
Positive Regulation Of Protein Localization
Regulation Of Immune Response
Plasma Membrane
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Projection Organization
Regulation Of Programmed Cell Death
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Regulation Of Organelle Organization
Negative Regulation Of Programmed Cell Death
Protein Serine/threonine Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Immune System Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Apoptotic Process
Establishment Or Maintenance Of Cell Polarity
Establishment Or Maintenance Of Apical/basal Cell Polarity
Regulation Of Cell Projection Organization
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Regulation Of Primary Metabolic Process
Regulation Of Innate Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
RNA Catabolic Process
Telomeric DNA Binding
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
Nucleobase-containing Compound Catabolic Process
Exon-exon Junction Complex
Macromolecule Catabolic Process
MRNA Transport
RNA Transport
Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Nucleobase-containing Compound Transport
MRNA Export From Nucleus
RNA Export From Nucleus
Regulation Of Gene Expression
MRNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Catabolic Process
Nuclear Export
Regulation Of Macromolecule Metabolic Process
RNA Metabolic Process
Positive Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of Metabolic Process
Regulation Of Glial Cell Proliferation
Macromolecule Metabolic Process
Positive Regulation Of RNA Splicing
Nuclear Transport
Nucleocytoplasmic Transport
Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Late Endosome To Lysosome Transport
Nucleic Acid Metabolic Process
Cytosol
Cytoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Response To Interleukin-1
Cytoplasmic Ribonucleoprotein Granule
Negative Regulation Of Biosynthetic Process
Cellular Localization
Intracellular Monoatomic Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Monoatomic Cation Homeostasis
Regulation Of Gliogenesis
Double-stranded DNA Helicase Activity
Supraspliceosomal Complex
VCB Complex
Regulation Of Telomere Maintenance
Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Macromolecule Biosynthetic Process
Golgi Vesicle Budding
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Tagcloud (Intersection)
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