PRKCI and RAB2A

Number of citations of the paper that reports this interaction (PubMedID 14570876)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PRKCI	RAB2A
Description		protein kinase C iota	RAB2A, member RAS oncogene family
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Brush Border Bicellular Tight Junction Cilium Microtubule Cytoskeleton Membrane Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Intercellular Bridge Apical Part Of Cell Extracellular Exosome Tight Junction Schaffer Collateral - CA1 Synapse Glutamatergic Synapse PAR Polarity Complex	Golgi Membrane Autophagosome Membrane Acrosomal Vesicle Nucleus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Establishment Of Cell Polarity Cellular Response To Insulin Stimulus Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Notch Signaling Pathway Positive Regulation Of D-glucose Import Secretion Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Cellular Response To Chemical Stress Response To Interleukin-1 Protein Localization To Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Macroautophagy Autophagosome-lysosome Fusion
Pathways		Pre-NOTCH Transcription and Translation p75NTR recruits signalling complexes Tight junction interactions KEAP1-NFE2L2 pathway	Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation
Drugs		Tamoxifen Staurosporine Bisindolylmaleimide I Dequalinium Benzoyl peroxide Fostamatinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Microalbuminuria ( 31511532) Prostate cancer ( 25939597) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)	Aspartate aminotransferase levels ( 33547301) Autoimmune thyroid disease ( 32581359) Estimated glomerular filtration rate ( 31152163) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Systemic sclerosis ( 31672989) Total cholesterol levels ( 29083408)
Interacting Genes		51 interacting genes: ADAP1 ANXA1 APP BAD CASK CASP8 CCNT1 CDC42 CDK7 CHUK CTBP1 FABP4 FCGR3A FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MAPT MARK4 MBP MEOX2 NACC1 NFKBIA PARD3 PARD6A PARD6B PARD6G PCM1 PDPK1 PNMA1 RAB2A RAB4A RAC1 RBM14 RHOQ SMG1 SMURF1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ	29 interacting genes: BLZF1 CBFB CCDC125 CEBPA CFL2 FAM114A1 FAM114A2 FRMD1 GAA GAPDH GARIN4 GARIN6 GDI2 GOLGA2 GORASP2 HES6 ICA1 MAPK6 MAPKAPK3 OTOS PMAIP1 PRKCI RBSN RGS2 SGSM2 STAMBPL1 TBC1D25 TMEM70 TRIM7
Entrez ID		5584	5862
HPRD ID		02105	01539
Ensembl ID		ENSG00000163558	ENSG00000104388
Uniprot IDs		P41743	P61019
PDB IDs		1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8 5LI1 5LI9 5LIH 6ILZ 8R3X 8R3Y	1Z0A
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Intracellular Signaling Cassette Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Intracellular Signal Transduction Immune System Process PAR Polarity Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Stress Regulation Of Gene Expression Positive Regulation Of Protein Localization Regulation Of Immune Response Plasma Membrane Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Projection Organization Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Organelle Organization Negative Regulation Of Programmed Cell Death Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Immune System Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Apoptotic Process Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Cell Projection Organization Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Regulation Of Primary Metabolic Process Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction
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