PRKCI and MAP2K5

Number of citations of the paper that reports this interaction (PMID 11158308)
16

Data Source:
HPRD (in vivo)

		PRKCI	MAP2K5
Gene Name		protein kinase C, iota	mitogen-activated protein kinase kinase 5
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Tight Junction Microtubule Cytoskeleton Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Protein Complex Intercellular Bridge Extracellular Vesicular Exosome	Intracellular Nucleus Spindle Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Phospholipid Binding Protein Domain Specific Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Cellular Response To Insulin Stimulus Cell Junction Assembly Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Glucose Import Secretion Neurotrophin TRK Receptor Signaling Pathway Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Response To Interleukin-1 Tight Junction Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Signal Transduction Heart Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cell junction organization Cell-cell junction organization Signalling by NGF p75NTR recruits signalling complexes Tight junction interactions p75NTR signals via NF-kB p75 NTR receptor-mediated signalling	Signalling to ERK5 Signalling by NGF NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS			Body mass index ( 22344219 20935630) Obesity ( 23563607) Restless legs syndrome ( 17637780 21779176)
Protein-Protein Interactions		41 interactors: ADAP1 ANXA1 APP BAD CASP8 CDC42 CDK7 CHUK FABP4 FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MARK4 MBP NFKBIA PARD3 PARD6A PARD6B PARD6G PDPK1 PNMA1 RAB2A RAB4A RAC1 RHOQ SMG1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ	15 interactors: ASRGL1 BAD CDC42BPB ESRRA MAP3K2 MAP3K3 MAPK7 PARD6A PRKCI PRKCZ RPL28 SQSTM1 STAMBP XRCC6 YWHAZ
Entrez ID		5584	5607
HPRD ID		02105	03951
Ensembl ID		ENSG00000163558	ENSG00000137764
Uniprot IDs		P41743	A6NK28 Q13163
PDB IDs		1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8	2NPT 2O2V 4IC7
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Defense Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Immune Response Regulation Of Cell Death Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune System Process Response To Stress Response To Stimulus Intracellular Signal Transduction Signaling Cellular Response To Organic Substance Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Positive Regulation Of Programmed Cell Death Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Death Positive Regulation Of Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Toll-like Receptor 3 Signaling Pathway Apoptotic Process Response To Fibroblast Growth Factor Negative Regulation Of Cell Death	Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Response To Growth Factor Signal Transduction Cellular Response To Stimulus Phosphorylation Protein Phosphorylation Signaling Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Signal Transduction Response To Stimulus Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Membrane Potential Positive Regulation Of Kinase Activity Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Endothelial Cell Apoptotic Process Response To Transforming Growth Factor Beta Positive Regulation Of Autophagy Positive Regulation Of Glucose Import Cellular Protein Modification Process Regulation Of Cellular Localization Positive Regulation Of Glucose Transport Viral Process Positive Regulation Of Transferase Activity
Tagcloud ?		abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse	amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse	amico atm dissect entered erg formalin fusions hiseq illumina maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?