PRKCI and ADAP1

Number of citations of the paper that reports this interaction (PMID 12893243)
2

Data Source:
HPRD (in vitro)

		PRKCI	ADAP1
Gene Name		protein kinase C, iota	ArfGAP with dual PH domains 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Tight Junction Microtubule Cytoskeleton Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Protein Complex Intercellular Bridge Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Phospholipid Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding Inositol 1,3,4,5 Tetrakisphosphate Binding
	Biological Process	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Cellular Response To Insulin Stimulus Cell Junction Assembly Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Glucose Import Secretion Neurotrophin TRK Receptor Signaling Pathway Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Response To Interleukin-1 Tight Junction Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Cell Surface Receptor Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity
Pathways		Cell junction organization Cell-cell junction organization Signalling by NGF p75NTR recruits signalling complexes Tight junction interactions p75NTR signals via NF-kB p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: ADAP1 ANXA1 APP BAD CASP8 CDC42 CDK7 CHUK FABP4 FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MARK4 MBP NFKBIA PARD3 PARD6A PARD6B PARD6G PDPK1 PNMA1 RAB2A RAB4A RAC1 RHOQ SMG1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ	23 interactors: ANP32A AP3B2 CSNK1A1 DVL3 GADD45A GOLGA2 GSK3B NCL PIK3CA PRKCA PRKCE PRKCI PRKCZ PRKD1 PSME3 PURA RANBP9 RPS9 SDCBP2 SF3A3 SRSF2 SUB1 SUPV3L1
Entrez ID		5584	11033
HPRD ID		02105	09733
Ensembl ID		ENSG00000163558	ENSG00000105963
Uniprot IDs		P41743	O75689
PDB IDs		1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8	3FEH 3FM8 3LJU 3MDB
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Defense Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Immune Response Regulation Of Cell Death Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune System Process Response To Stress Response To Stimulus Intracellular Signal Transduction Signaling Cellular Response To Organic Substance Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Positive Regulation Of Programmed Cell Death Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Death Positive Regulation Of Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Toll-like Receptor 3 Signaling Pathway Apoptotic Process Response To Fibroblast Growth Factor Negative Regulation Of Cell Death	Peptidyl-serine Phosphorylation Intracellular Signal Transduction Intracellular Transport Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Cell Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Cellular Localization Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Regulation Of Glucose Import Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Regulation Of Metabolic Process Platelet Activation Response To Fibroblast Growth Factor Negative Regulation Of Glial Cell Apoptotic Process Anatomical Structure Morphogenesis Positive Regulation Of Phospholipase Activity
Tagcloud ?		abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse
Tagcloud (Difference) ?		abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse
Tagcloud (Intersection) ?