DOK5 and RET

Number of citations of the paper that reports this interaction (PMID 11470823)
30

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		DOK5	RET
Gene Name		docking protein 5	ret proto-oncogene
Image
Gene Ontology Annotations	Cellular Component		Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Receptor Complex Membrane Raft
	Molecular Function	Receptor Signaling Protein Activity Insulin Receptor Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Calcium Ion Binding Protein Binding ATP Binding
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development	MAPK Cascade Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Ureter Maturation Response To Drug Neuron Maturation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs			Imatinib
Diseases
GWAS		Functional MRI ( 20215924)	Hirschsprung's disease ( 19196962)
Protein-Protein Interactions		9 interactors: BNIP3L CCDC85B EGFR IGF1R INSR NTRK2 NTRK3 OPRM1 RET	36 interactors: AKAP5 CBL CBLB CRK DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG MAPK1 MAPK14 MAPK3 MAPK8 NOTCH2NL NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF SHC1 SHC3 SRC STAT3
Entrez ID		55816	5979
HPRD ID		16317	01266
Ensembl ID		ENSG00000101134	ENSG00000165731
Uniprot IDs		Q9P104	P07949 Q9BTX6
PDB IDs		1J0W	1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Protein Kinase B Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Digestive System Development Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Organic Substance Exocrine System Development Regulation Of Cell Migration Response To Growth Factor Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Motility Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of DNA Replication Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Protein Kinase B Signaling Exocrine Pancreas Development Regulation Of Catalytic Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Cell Proliferation Generation Of Neurons Positive Regulation Of Cellular Biosynthetic Process Neurogenesis Regulation Of Signal Transduction Positive Regulation Of Neurogenesis Regulation Of Intracellular Signal Transduction Male Sex Determination Regulation Of DNA Replication Negative Regulation Of Cell Death Phosphorylation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Response To Peptide Response To Peptide Hormone Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Positive Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Response To Organonitrogen Compound Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Stimulus Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signal Transduction Response To Hormone Positive Regulation Of Kinase Activity MAPK Cascade Regulation Of Immune Response Response To Wounding Ras Protein Signal Transduction Positive Regulation Of Transferase Activity
Tagcloud ?		adrenal cdh11 combine copy dsc3 epigenomic etv1 exploration gnas h3k27 h3k27me3 h3k4me3 hoxa9 igf2 insm1 instance mark medulla methylations ntrk1 pheochromocytoma ptpre rassf2 ret silenced tgif1 tnfrsf10b trimethylase trimethylated	coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Difference) ?		adrenal cdh11 combine copy dsc3 epigenomic etv1 exploration gnas h3k27 h3k27me3 h3k4me3 hoxa9 igf2 insm1 instance mark medulla methylations ntrk1 pheochromocytoma ptpre rassf2 silenced tgif1 tnfrsf10b trimethylase trimethylated	coimmunoprecipitation crest displays docking enlightening fmtc gdnf grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements separately shc
Tagcloud (Intersection) ?		ret