DOK5 and CDCA4

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DOK5	CDCA4
Description		docking protein 5	cell division cycle associated 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Differentiation Positive Regulation Of MAPK Cascade Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Positive Regulation Of DNA-templated Transcription
Pathways		RET signaling
Drugs
Diseases
GWAS		Celiac disease ( 23936387) Erectile dysfunction ( 30583798) Functional MRI ( 20215924) HDL cholesterol levels in HIV infection ( 33109212)	Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Leukocyte telomere length ( 32109421)
Interacting Genes		20 interacting genes: AHDC1 ATF3 BNIP3L CCDC85B CDCA4 DOK3 EGFR FANCG IGF1R INSR NTRK2 NTRK3 OLIG1 OPRM1 PFDN5 RAI2 RET SCOC TSC1 WIZ	25 interacting genes: AIRIM BFSP2 DOK5 ENKD1 FAM222B FARS2 FNDC11 KAT2B KDM1A KLHL42 MKRN3 PARD6B PRMT6 SEPHS1 SHC3 SUOX SUPT7L SUV39H1 SUV39H2 TCAP TRIM28 TXN2 XPO1 YPEL3 ZNF451
Entrez ID		55816	55038
HPRD ID		16317	13015
Ensembl ID		ENSG00000101134	ENSG00000170779
Uniprot IDs		Q9P104	Q9BXL8
PDB IDs		1J0W
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Axon Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Complex Neurotrophin Receptor Activity Neurotrophin Binding Insulin Binding Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Kinase Activity Dendritic Spine Maintenance Action Potential Propagation Neuronal Action Potential Propagation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Insulin-like Growth Factor I Binding Insulin Receptor Substrate Binding Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Endosome Phosphatidylinositol 3-kinase Binding Myelination Axon Ensheathment Myelination In Peripheral Nervous System Learning Or Memory Positive Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Endosome Membrane Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Nervous System Process Protein Autophosphorylation Amyloid-beta Clearance Mechanoreceptor Differentiation Cognition Positive Regulation Of Cell Motility Response To Growth Factor Positive Regulation Of Cell Population Proliferation Neurotrophin Signaling Pathway Positive Regulation Of Locomotion	Epigenetic Programming Of Gene Expression Histone H3K9 Trimethyltransferase Activity Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Regulation Of DNA Repair Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Transcription By Glucose Histone H3K9 Methyltransferase Activity Epigenetic Programming In The Zygotic Pronuclei Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Binding I Band SAGA Complex Transcription Coactivator Activity Regulation Of Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization
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