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DOK5 and NTRK2
Number of citations of the paper that reports this interaction (PubMedID
16647839
)
0
Data Source:
HPRD
(two hybrid, in vitro)
DOK5
NTRK2
Description
docking protein 5
neurotrophic receptor tyrosine kinase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Postsynaptic Density
Membrane
Axon
Dendrite
Early Endosome Membrane
Cell Projection
Terminal Bouton
Dendritic Spine
Receptor Complex
Axon Terminus
Synapse
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Nucleotide Binding
Protease Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Neurotrophin Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Homodimerization Activity
Neurotrophin Binding
Brain-derived Neurotrophic Factor Binding
Brain-derived Neurotrophic Factor Receptor Activity
Biological Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Neuron Differentiation
Positive Regulation Of MAPK Cascade
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Vasculogenesis
Neuron Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Nervous System Development
Learning
Circadian Rhythm
Feeding Behavior
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Glutamate Secretion
Regulation Of Metabolic Process
Neuronal Action Potential Propagation
Central Nervous System Neuron Development
Cerebral Cortex Development
Myelination In Peripheral Nervous System
Cell Differentiation
Neuron Differentiation
Brain-derived Neurotrophic Factor Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Mechanoreceptor Differentiation
Regulation Of GTPase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Retinal Rod Cell Development
Protein Autophosphorylation
Oligodendrocyte Differentiation
Peripheral Nervous System Neuron Development
Positive Regulation Of Axonogenesis
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Retina Development In Camera-type Eye
Long-term Synaptic Potentiation
Cellular Response To Amino Acid Stimulus
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Negative Regulation Of Amyloid-beta Formation
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Negative Regulation Of Anoikis
Pathways
RET signaling
PIP3 activates AKT signaling
NGF-independant TRKA activation
Constitutive Signaling by Aberrant PI3K in Cancer
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
BDNF activates NTRK2 (TRKB) signaling
NTF3 activates NTRK2 (TRKB) signaling
NTF4 activates NTRK2 (TRKB) signaling
Activated NTRK2 signals through RAS
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FYN
NTRK2 activates RAC1
NTRK2 activates RAC1
Activated NTRK2 signals through CDK5
Drugs
Amitriptyline
Esketamine
Entrectinib
Fostamatinib
Larotrectinib
Diseases
Neuroblastoma
GWAS
Celiac disease (
23936387
)
Erectile dysfunction (
30583798
)
Functional MRI (
20215924
)
HDL cholesterol levels in HIV infection (
33109212
)
Birth weight (
24950379
)
Body mass index (
25760438
28892062
)
Body size at age 10 (
32376654
)
Gout (normal type) (
32238385
)
Lifetime anxiety disorder (
31748690
)
Menarche (age at onset) (
25231870
)
Parkinson's disease progression (cognitive) (
33111402
)
Refractive error (
32231278
)
Serum metabolite concentrations in chronic kidney disease (
29545352
)
Type 2 diabetes (
31118516
)
Waist-to-hip circumference ratio (recreational physical activity interaction) (
23192594
)
Interacting Genes
20 interacting genes:
AHDC1
ATF3
BNIP3L
CCDC85B
CDCA4
DOK3
EGFR
FANCG
IGF1R
INSR
NTRK2
NTRK3
OLIG1
OPRM1
PFDN5
RAI2
RET
SCOC
TSC1
WIZ
35 interacting genes:
AP1B1
BDNF
DOK5
DYNLL1
EGFR
ERBB2
ERBB4
FRS2
FRS3
FYN
GIPC1
KIDINS220
NCK1
NCK2
NDFIP1
NGFR
NMNAT1
NTF3
NTF4
PIK3R1
PLCG1
POLR2G
PTPN1
PTPN11
RASGRF1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TRAF6
UBB
USP8
Entrez ID
55816
4915
HPRD ID
16317
02712
Ensembl ID
ENSG00000101134
ENSG00000148053
Uniprot IDs
Q9P104
A0A8I5KR47
A0A8I5KUZ1
A0A8I5KZB7
A0A8J8YUT9
Q16620
Q548C2
Q5VWE5
PDB IDs
1J0W
1HCF
1WWB
2MFQ
4ASZ
4AT3
4AT4
4AT5
5MO9
8OYD
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Receptor Complex
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Insulin Receptor Activity
Axon
Regulation Of Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Insulin Receptor Complex
Neurotrophin Receptor Activity
Neurotrophin Binding
Insulin Binding
Protein Kinase Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Kinase Activity
Dendritic Spine Maintenance
Action Potential Propagation
Neuronal Action Potential Propagation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Insulin-like Growth Factor I Binding
Insulin Receptor Substrate Binding
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Endosome
Phosphatidylinositol 3-kinase Binding
Myelination
Axon Ensheathment
Myelination In Peripheral Nervous System
Learning Or Memory
Positive Regulation Of Cell Junction Assembly
Cellular Response To Growth Factor Stimulus
Endosome Membrane
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Migration
Nervous System Process
Protein Autophosphorylation
Amyloid-beta Clearance
Mechanoreceptor Differentiation
Cognition
Positive Regulation Of Cell Motility
Response To Growth Factor
Positive Regulation Of Cell Population Proliferation
Neurotrophin Signaling Pathway
Positive Regulation Of Locomotion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Cell Communication
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Receptor Tyrosine Kinase Binding
Positive Regulation Of Intracellular Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of MAPK Cascade
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Apoptotic Process
Neurotrophin Signaling Pathway
Regulation Of Programmed Cell Death
Signal Transduction
Regulation Of Signal Transduction
Nerve Growth Factor Signaling Pathway
Neurotrophin TRKA Receptor Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Response To Growth Factor
Regulation Of Protein Localization
Cell Projection Organization
Cellular Response To Epidermal Growth Factor Stimulus
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Cytosol
Nerve Growth Factor Receptor Binding
Response To Epidermal Growth Factor
Insulin Receptor Binding
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Metabolic Process
Ephrin Receptor Binding
Negative Regulation Of Developmental Process
Signaling Adaptor Activity
Modulation Of Chemical Synaptic Transmission
Regulation Of Cell Population Proliferation
Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Cellular Localization
Neuron Projection Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Negative Regulation Of PERK-mediated Unfolded Protein Response
Cell Projection Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Endosome Membrane
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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