DOK5 and SCOC

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		DOK5	SCOC
Description		docking protein 5	short coiled-coil protein
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Golgi Membrane Nucleoplasm Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Differentiation Positive Regulation Of MAPK Cascade Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Positive Regulation Of Macroautophagy Regulation Of Protein Complex Stability
Pathways		RET signaling	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Celiac disease ( 23936387) Erectile dysfunction ( 30583798) Functional MRI ( 20215924) HDL cholesterol levels in HIV infection ( 33109212)	Malaria ( 31844061) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		20 interacting genes: AHDC1 ATF3 BNIP3L CCDC85B CDCA4 DOK3 EGFR FANCG IGF1R INSR NTRK2 NTRK3 OLIG1 OPRM1 PFDN5 RAI2 RET SCOC TSC1 WIZ	14 interacting genes: ARL1 BFSP2 DDIT4L DOK5 FEZ1 ITSN1 KIFC3 KRT40 MAPK8 PSMC5 SCHIP1 SIKE1 TCF4 TRAPPC6A
Entrez ID		55816	60592
HPRD ID		16317	18027
Ensembl ID		ENSG00000101134	ENSG00000153130
Uniprot IDs		Q9P104	A0A0C4DGB0 A0A804E055 Q9UIL1
PDB IDs		1J0W	4BWD 7AA7
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Insulin Receptor Activity Axon Regulation Of Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Complex Neurotrophin Receptor Activity Neurotrophin Binding Insulin Binding Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Kinase Activity Dendritic Spine Maintenance Action Potential Propagation Neuronal Action Potential Propagation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Insulin-like Growth Factor I Binding Insulin Receptor Substrate Binding Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Endosome Phosphatidylinositol 3-kinase Binding Myelination Axon Ensheathment Myelination In Peripheral Nervous System Learning Or Memory Positive Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Endosome Membrane Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Nervous System Process Protein Autophosphorylation Amyloid-beta Clearance Mechanoreceptor Differentiation Cognition Positive Regulation Of Cell Motility Response To Growth Factor Positive Regulation Of Cell Population Proliferation Neurotrophin Signaling Pathway Positive Regulation Of Locomotion
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