LRIF1 and CDKN2C

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LRIF1	CDKN2C
Description		ligand dependent nuclear receptor interacting factor 1	cyclin dependent kinase inhibitor 2C
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Barr Body Nucleus Nucleoplasm Chromosome Nuclear Matrix Centriolar Satellite	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Nuclear Retinoic Acid Receptor Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome	Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Oligodendrocyte Differentiation Stem Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Stem Cell Proliferation
Pathways			Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs
Diseases
GWAS		Bone mineral content ( 31790847) Intraocular pressure ( 30591961)	Atrial fibrillation ( 29290336) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 33713608 31562340) Hip circumference adjusted for BMI ( 34021172) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 21076409 27659466) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Thyroid stimulating hormone levels ( 32769997) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		143 interacting genes: AKR1C3 ANKRD24 ANXA1 ANXA7 APLP1 ARL3 ATF3 ATP1B1 BANP BARD1 BMI1 BOC BRD7 BRMS1 CALR CBX1 CBX5 CCDC106 CDC42 CDKN1A CDKN2C CETN3 CHD3 CKMT2 COX17 CPE CRACR2A CRADD CRCP CRCT1 CRIPTO DDIT4 EIF6 ESR1 ETHE1 FAS FEZ1 FHL2 FOSL2 FXR1 GADD45G GC GIT1 GPRASP2 GSTM4 H3-4 HAP1 HLA-DQA1 HMGB1 HMOX2 HSPB1 HSPB3 HSPBP1 HSPE1 ID2 IMMT KAT5 KAT7 KBTBD7 KCNE3 KLHL20 KLK10 LAMA4 LAMTOR5 MAD2L1BP MLLT3 MNAT1 MOB4 MPHOSPH6 MRPS12 MRPS6 NACA NOC2L NR3C1 NRBP1 NTAQ1 PAEP PAFAH1B3 PCDHA4 PDCD5 PFDN1 PFN1 PIAS4 PIN1 PLEKHA4 PNP POLR1C POLR2C POLR3F PPARG PQBP1 PRKAB2 PRKAR2A PRMT1 PSG9 PSMD11 PSMD2 PSPC1 RAB27A RAP1B RARA RBM5 RCC1 RFC5 RHOH RIT1 RNF10 RORA RPA2 RPL37A RPLP1 RRM1 S100A8 SAT1 SELENBP1 SERPINB9 SETDB1 SMN1 SNRPN SNU13 SPATA18 SPG7 STX5 SULT1E1 SUPT4H1 SUV39H2 TAF1D TGIF1 THRB TK1 TRBV2 TRDMT1 TSC22D1 TSEN15 TSPAN6 UBE2V2 UNC119 VIM VPS26C WDR62 WWC1 ZNF24 ZNF410	59 interacting genes: AHCYL1 AKT1 ANGPTL4 APLP1 ARNT ATM ATR CCDC90B CCND2 CCNE1 CDK4 CDK6 CDKN2A CDKN2B COPS6 CRX CTDSP1 DRAP1 EPHA2 ERBB2 FGFR4 GDF9 GOPC GREB1 GRM1 KRT31 LATS2 LNX2 LRIF1 LY96 MAP2K3 MAP2K5 MAPK10 MAPK8 MTA3 MYC NAGK NAT2 NF2 NIF3L1 PBX4 PDGFRA PLEKHG4 POU6F2 PPP2CA RAF1 RBM48 REL SCGB2A2 SNU13 SORBS3 ST14 STK11 TCF12 TCF4 TLE1 TP53 UBC UNC119
Entrez ID		55791	1031
HPRD ID		17975	04534
Ensembl ID		ENSG00000121931	ENSG00000123080
Uniprot IDs		Q5T3J3	P42773 Q6ICV4
PDB IDs			1BU9 1G3N 1IHB 1MX2 1MX4 1MX6
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Protein Binding Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Binding Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Nuclear Receptor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cytosol Positive Regulation Of Apoptotic Process Nucleolus Negative Regulation Of Transcription By RNA Polymerase II Biological_process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Development Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Hemopoiesis Chromatin Organization Regulation Of Cell Differentiation Mononuclear Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation DNA-directed RNA Polymerase Activity Positive Regulation Of Biosynthetic Process Chromatin Remodeling Regulation Of Cell Cycle Process Regulation Of DNA Repair Regulation Of Cell Cycle G1/S Phase Transition	Kinase Activity Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle Phase Transition Cellular Senescence Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Protein Phosphorylation Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Signal Transduction MAPK Cascade Regulation Of Cell Cycle Process Replicative Senescence Positive Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Metabolic Process Response To Radiation Regulation Of Cell Population Proliferation G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cell Communication Response To UV Positive Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Light Stimulus Cellular Response To Radiation Regulation Of Signaling Regulation Of Cell Communication ATP Binding Regulation Of Catalytic Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition
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